GAB2 Antibody (N-term)
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
WB, FC, ELISA
KIAA0571 antibody; GRB2-associated-binding protein 2 antibody; GRB2-associated binder 2 antibody; Growth factor receptor bound protein 2-associated protein 2 antibody; pp100 antibody; GAB2 antibody; KIAA0571 antibody
This GAB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3-30 amino acids from the N-terminal region of human GAB2.
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
WB: 1:1000, FC: 1:10~50
Western blot analysis of GAB2 Antibody (N-term) (Cat. #120063) in MCF7 cell line lysates (35ug/lane). GAB2 (arrow) was detected using the purified Pab.
GAB2 Antibody (N-term) (Cat.#120063) flow cytometry analysis of MDA-MB231 cells (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.
- Dunn GP, Cheung HW, Agarwalla PK. In vivo multiplexed interrogation of amplified genes identifies GAB2 as an ovarian cancer oncogene. Proceedings of the National Academy of Sciences of the United States of America. 111(3):1102-7. 2014.
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