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  • GAB2 Antibody (N-term)
  • GAB2 Antibody (N-term)

GAB2 Antibody (N-term)

Cat.#: 120063

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Special Price 372.6 USD

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Product Information

  • Product Name
    GAB2 Antibody (N-term)
  • Documents
  • Description
    Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
  • Tested applications
    WB, FC, ELISA
  • Species reactivity
    Human
  • Alternative names
    KIAA0571 antibody; GRB2-associated-binding protein 2 antibody; GRB2-associated binder 2 antibody; Growth factor receptor bound protein 2-associated protein 2 antibody; pp100 antibody; GAB2 antibody; KIAA0571 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This GAB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3-30 amino acids from the N-terminal region of human GAB2.
  • Clonality
    Polyclonal
  • Formulation
    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
  • Storage instructions
    Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
  • Applications
    WB: 1:1000, FC: 1:10~50
  • Validations

    Western blot analysis of GAB2 Antibody (N-term) (Cat. #120063) in MCF7 cell line lysates (35ug/lane). GAB2 (arrow) was detected using the purified Pab.

    Western blot analysis of GAB2 Antibody (N-term) (Cat. #120063) in MCF7 cell line lysates (35ug/lane). GAB2 (arrow) was detected using the purified Pab.

    GAB2 Antibody (N-term) (Cat.#120063) flow cytometry analysis of MDA-MB231 cells (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

    GAB2 Antibody (N-term) (Cat.#120063) flow cytometry analysis of MDA-MB231 cells (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

  • Background
    Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.
  • References
    • Dunn GP, Cheung HW, Agarwalla PK. In vivo multiplexed interrogation of amplified genes identifies GAB2 as an ovarian cancer oncogene. Proceedings of the National Academy of Sciences of the United States of America. 111(3):1102-7. 2014.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"