Human 4E-BP1/EIF4EBP1 (His Tag) recombinant protein

Cat.#: 500121

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Product Information

  • Product Name
    Human 4E-BP1/EIF4EBP1 (His Tag) recombinant protein
  • Documents
  • Description
    Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
  • Protein name
    Eukaryotic translation initiation factor 4E-binding protein 1
  • Protein short names
    MGC4316; 4EBP1; AA959816; EIF4EBP1; PHAS-I; 4E-BP1; BP-1
  • Uniprot ID
    Q13541
  • Gene Name
    EIF4EBP1
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human 4EBP1 (NP_004086.1) (Ser 2-Ile 118) with a N-terminal polyhistidine tag was expressed.
  • Protein Species
    Human
  • Molecular weight
    The secreted recombinant human 4EBP1 comprises 124 amino acids with a predicted molecular mass of 13.4 kDa. It migrates as an approximately 19 kDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 90 % as determined by SDS-PAGE
  • Validations

    Human 4E-BP1 / EIF4EBP1 Protein (His Tag) SDS-PAGE

    Human 4E-BP1 / EIF4EBP1 Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"