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  • Mouse Ephrin-B2 (His Tag) recombinant protein

Mouse Ephrin-B2 (His Tag) recombinant protein

Cat.#: 500099

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Product Information

  • Product Name
    Mouse Ephrin-B2 (His Tag) recombinant protein
  • Documents
  • Description
    Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.
  • Protein name
    Ephrin-B2
  • Protein short names
    EFNB2; MGC126228; HTKL; HTK-L; LERK-5; ELF-2; LERK5; NLERK-1; MGC126227; RP11-272L14.1; EPLG5; MGC126226; EPL5; EPHRIN-B2
  • Uniprot ID
    Q4FJM3
  • Gene Name
    Efnb2; Elf2; Epl5; Eplg5; Htkl; Lerk5
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mouse EFNB2 (NP_034241.2) extracellular domain (Met 1-Ala 232) was fused with a polyhistidine tag at the C-terminus.
  • Protein Species
    Mouse
  • Molecular weight
    The secreted recombinant mouse EFNB2 comprises 215 amino acids and has a predicted molecular mass of 23.5 kDa. As a result of glycosylation, the apparent molecular mass of rmEFNB2 is approximately 30-40 kDa in SDS-PAGE under reducing conditions.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Activity
    Measured by its ability to compete with mouse EFNB2-Fc for binding to immobilized mouse EPHB4 in a functional ELISA assay.
  • Validations

    Mouse Ephrin-B2 / EFNB2 Protein (His Tag) SDS-PAGE

    Mouse Ephrin-B2 / EFNB2 Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"