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Product Name
Mouse Ephrin-B1/EFNB1 (His Tag) recombinant protein
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Description
Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to the receptor tyrosine kinases EPHB3 (preferred), EPHB1 and EPHA1. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons.
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Protein name
Ephrin-B1
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Protein short names
EFNB1; RP3-496G1.1; CEK5-L; EPL2; EPHRIN B1; EFB1; EFL-3; LERK-2; EPHRIN-B1; RP23-110A15.1; CFNS; LERK2; EFL3; STRA1; MGC8782; ELK-L; EPLG2; CFND
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Uniprot ID
Q544L9
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Gene Name
Efnb1; Epl2; Eplg2; Lerk2; Stra1
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse EFNB1 (NP_034240.1) extracellular domain (Met 1-Ser 229) was expressed, fused with a polyhistidine tag at the C-terminus.
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Protein Species
Mouse
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Molecular weight
The secreted recombinant mouse EFNB1 consists of 211 amino acids and has a predicted molecular mass of 23.3 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmEFNB1 is approximately 33-38 kDa due to glycosylation.
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Purity
> 95 % as determined by SDS-PAGE
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Activity
Measured by its ability to compete with mouse EphrinB1 / Fc for binding to immobilized mouse EphB3 in a functional ELISA assay.
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Validations
Mouse Ephrin-B1 / EFNB1 Protein (His Tag) SDS-PAGE
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