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  • Human Ephrin-A1/EFNA1 (His Tag) recombinant protein

Human Ephrin-A1/EFNA1 (His Tag) recombinant protein

Cat.#: 500400

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Product Information

  • Product Name
    Human Ephrin-A1/EFNA1 (His Tag) recombinant protein
  • Documents
  • Description
    Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.
  • Protein name
    Ephrin-A1
  • Protein short names
    AI325262; TNFAIP4; EPHRIN-A1; EPLG1; EFNA1; EPHRIN A1; EFL1; B61; ECKLG; EPL1; LERK-1; LERK1
  • Uniprot ID
    P20827
  • Gene Name
    EFNA1; EPLG1; LERK1; TNFAIP4
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human Ephrin-A1 (NP_004419.2) without the propeptide (Met 1-Ser182) was expressed, fused with a polyhistidine tag at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human Ephrin-A1 comprises 175 amino acids a predicted molecular mass of 20.8 kDa. As a result of glycosylation, rh Ephrin-A1 migrates as an approximately 26 kDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 97 % as determined by SDS-PAGE
  • Activity
    Measured by its ability to compete with human EFNA1 for binding to immobilized human EphA2 in a functional ELISA assay.
  • Validations

    Human Ephrin-A1 / EFNA1 Protein (His Tag) SDS-PAGE

    Human Ephrin-A1 / EFNA1 Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"