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  • Human ADAM15 (His Tag) recombinant protein

Human ADAM15 (His Tag) recombinant protein

Cat.#: 502188

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Product Information

  • Product Name
    Human ADAM15 (His Tag) recombinant protein
  • Documents
  • Description
    Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain.
  • Protein name
    Disintegrin and metalloproteinase domain-containing protein 15
  • Protein short names
    MDC15; METARGIDIN; ADAM15; RP11-540D14.1
  • Uniprot ID
    Q13444
  • Gene Name
    ADAM15; MDC15
  • Source/Expression Host
    CHO Stable Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human ADAM15 (Q13444-1) (Met 1-Thr 696) precursor was expressed, with a C-terminal polyhistidine tag.
  • Protein Species
    Human
  • Molecular weight
    The secreted recombinant human ADAM15 (mature form) comprises 501 amino acids after proteolytic of the signal peptide and pro peptide and has a predicted molecular mass of 54 kDa. As a result of glycosylation, rhADAM15 migrates as an approximately 65-70 kDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Validations

    Human ADAM15 Protein (His Tag) SDS-PAGE

    Human ADAM15 Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"