Cynomolgus CD80/B7-1 (His Tag) recombinant protein
The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. As costimulatory ligands, B7-1 which exists predominantly as dimer and the related protein B7-2, interact with the costimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus constitute one of the dominant pathways that regulate T cell activation and tolerance, cytokine production, and the generation of CTL. The B7/CD28/CTLA4 pathway has the ability to both positively and negatively regulate immune responses. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.
Protein short names
LY53; LY-53; MIC17; CD80; CD28L; BB1; B7; B7.1; B7-1; LAB7; TSA1; B71; CD28LG1; CD28LG
A DNA sequence encoding the cynomolgus CD80 (Met1-Asn242) was expressed with a polyhistidine tag at the C-terminus.
The recombinant cynomolgus CD80 consists 219 amino acids and predicts a molecular mass of 25.4 kDa.
> 95 % as determined by SDS-PAGE.
CD80 protein SDS-PAGE
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