Cynomolgus CD80/B7-1 (His Tag) recombinant protein

Cynomolgus CD80/B7-1 (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. As costimulatory ligands, B7-1 which exists predominantly as dimer and the related protein B7-2, interact with the costimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus constitute one of the dominant pathways that regulate T cell activation and tolerance, cytokine production, and the generation of CTL. The B7/CD28/CTLA4 pathway has the ability to both positively and negatively regulate immune responses. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.

LY53; LY-53; MIC17; CD80; CD28L; BB1; B7; B7.1; B7-1; LAB7; TSA1; B71; CD28LG1; CD28LG

Human Cells

A DNA sequence encoding the cynomolgus CD80 (Met1-Asn242) was expressed with a polyhistidine tag at the C-terminus.

Cynomolgus

The recombinant cynomolgus CD80 consists 219 amino acids and predicts a molecular mass of 25.4 kDa.

> 95 % as determined by SDS-PAGE.