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Rat CNTF/Ciliary Neurotrophic Factor recombinant protein

Cat.#: 500106

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Product Information

  • Product Name
    Rat CNTF/Ciliary Neurotrophic Factor recombinant protein
  • Documents
  • Description
    CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
  • Protein name
    Ciliary neurotrophic factor
  • Protein short names
    HCNTF; CNTF; MGC41235; AI429687
  • Uniprot ID
    P20294
  • Gene Name
    Cntf
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the rat CNTF (P20294) (Met 1-Met 200) was expressed and purified.
  • Protein Species
    Rat
  • Molecular weight
    The recombinant rat CNTF consisting of 200 amino acids and has a calculated molecular mass of 22.9 kDa. It migrates as an approximately 24 kDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 92 % as determined by SDS-PAGE
  • Activity
    1. Measured by its binding ability in a functional ELISA. Immobilized rat CNTF (Cat: 500106) at 10 μg/ml (100 μl/well) can bind biotinylated rat CNTFR-His (aa 1-346) (Cat: 501299) with a linear range of 1.56-50.0 ng/ml.
    2. Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is typically 10-40 ng/ml.
  • Validations

    Rat CNTF / Ciliary Neurotrophic Factor Protein SDS-PAGE

    Rat CNTF / Ciliary Neurotrophic Factor Protein SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"