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  • Human LFA-3 / CD58 (Fc Tag) recombinant protein

Human LFA-3 / CD58 (Fc Tag) recombinant protein

Cat.#: 501121

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Product Information

  • Product Name
    Human LFA-3 / CD58 (Fc Tag) recombinant protein
  • Documents
  • Description
    CD53 is a member of the transmembrane 4 superfamily, also called the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. These proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. CD53 is a cell surface glycoprotein that is known to complex with integrins. Familial deficiency of CD53 gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. CD53 contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation.
  • Protein name
    CD58 protein
  • Protein short names
    CD58 MOLECULE; LFA3; SURFACE GLYCOPROTEIN LFA-3; CD58; RP5-1086K13.2; AG3; CD58 ANTIGEN; LFA-3; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN 3
  • Uniprot ID
    Q9BRW0
  • Gene Name
    CD58
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human CD58 (Q9BRW0) (Met1-Arg215) was expressed with the Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human CD58/Fc is a disulfide-linked homodimer. The reduced monomer comprises 428 amino acids and has a predicted molecular mass of 48.5 kDa. The apparent molecular mass of the protein is approximately 68 kDa in SDS-PAGE under reducing conditions.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Activity
    1. Measured by its binding ability in a functional ELISA. Immobilized human CD2-His (Cat:502112) at 10 μg/ml (100 μl/well) can bind human CD58-Fc, The EC50 of human CD58-Fc is 0.04-0.1 μg/ml.
    2. Measured by its binding ability in a functional ELISA. Immobilized Cynomolgus CD2-His (Cat:502266) at 10 μg/ml (100 μl/well) can bind human CD58-Fc, The EC50 of human CD58-Fc is 0.04-0.10 μg/ml.
  • Validations

    Human LFA-3 / CD58 Protein (Fc Tag) SDS-PAGE

    Human LFA-3 / CD58 Protein (Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"