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  • Human CSNK2A1 (GST Tag) recombinant protein

Human CSNK2A1 (GST Tag) recombinant protein

Cat.#: 500524


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Product Information

  • Product Name
    Human CSNK2A1 (GST Tag) recombinant protein
  • Documents
  • Description
    Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation. Plays an important role in the circadian clock function by phosphorylating ARNTL/BMAL1 at 'Ser-90' which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry.
  • Protein name
    Casein kinase II subunit alpha
  • Protein short names
    CK II ALPHA; CSNK2A1; RP23-452D3.3; CSNK2A3; MGC102141; CKII; CSNK2A1-RS4; CK2A1
  • Uniprot ID
  • Gene Name
    CSNK2A1; CK2A1
  • Source/Expression Host
    Baculovirus-Insect Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human CSNK2A1 isoform 1 (NP_808227.1) (Met 1-Gln 391) was fused with the GST tag at the N-terminus.
  • Protein Species
  • Molecular weight
    The recombinant human CSNK2A1/GST chimera consists of 616 amino acids and predicts a molecular mass of 71.4 kDa. It migrates as an approximately 65 kDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 93 % as determined by SDS-PAGE
  • Activity
    The specific activity was determined to be 9 nmol/min/mg using casein as substrate.
  • Validations

    Human CSNK2A1 / CK2A1 Protein (GST Tag) SDS-PAGE

    Human CSNK2A1 / CK2A1 Protein (GST Tag) SDS-PAGE