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Mouse BCL2L1/Bcl-XL (aa 1-212, His Tag) recombinant protein

Cat.#: 500094

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Product Information

  • Product Name
    Mouse BCL2L1/Bcl-XL (aa 1-212, His Tag) recombinant protein
  • Documents
  • Description
    Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.
  • Protein name
    Bcl-2-like protein 1
  • Protein short names
    BCLX; BCL-XS; BCL(X)L; RP5-857M17.3; BCL2-L-1; BCL-X; RP23-106A3.4; PPP1R52; DKFZP78; BCLXS; BCL2L; BCL-XL; MGC113803; BCLXL; BCL-XL/S
  • Uniprot ID
    Q64373
  • Gene Name
    Bcl2l1; Bcl2l; Bclx
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mouse BCL2L1 (Q64373-1) (Met 1-Arg 212) was expressed, with a C-terminal polyhistidine tag.
  • Protein Species
    Mouse
  • Molecular weight
    The recombinant mouse BCL2L1 comprises 222 amino acids and has a calculated molecular mass of 25.2 kDa. It migrates as an approximately 33 kDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Activity
    1. Measured by its binding ability in a functional ELISA.
    2. Immobilized human BID at 10 μg/mL (100 μl/well) can bind  biotinylated mouse BCL2L1, The EC50 of biotinylated mouse BCL2L1 is 5.6 ng/mL.
    3. Immobilized mouse BID at 10 μg/mL (100 μl/well) can bind  biotinylated mouse BCL2L1, The EC50 of biotinylated mouse BCL2L1 is 7.1 ng/mL.
  • Validations

    Mouse BCL2L1 / Bcl-XL Protein (aa 1-212, His Tag) SDS-PAGE

    Mouse BCL2L1 / Bcl-XL Protein (aa 1-212, His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"