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  • Anti-VE-Cadherin/CD144 antibody

Anti-VE-Cadherin/CD144 antibody

Cat.#: 103723

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Product Information

  • Product Name
    Anti-VE-Cadherin/CD144 antibody
  • Documents
  • Description
    Rabbit polyclonal to VE-Cadherin/CD144
  • Tested applications
    ELISA
  • Species reactivity
    Mouse VE-Cadherin / CD144 / CDH5
  • Alternative names
    7B4 antibody; CD144 antibody; 7B4 antibody; Vec antibody; VECD antibody; Cd144 antibody; VEcad antibody; VE-Cad antibody; AA408225 antibody; 7B4 antibody; 7B4 antibody; AA408225 antibody; Cd144 antibody; CD144 antibody; Cdh5 antibody; CDH5 antibody; FLJ17376 antibody; Vec antibody; VE-Cad antibody; VE-Cadherin antibody; VE-Cadherin antibody; VECD antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    Produced in rabbits immunized with purified, recombinant Mouse VE-Cadherin / CD144 / CDH5 (rM VE-Cadherin / CD144 / CDH5; NP_033998.2; Met 1-Ala 592). VE-Cadherin / CD144 / CDH5 specific IgG was purified by Mouse VE-Cadherin / CD144 / CDH5 affinity chromatography.
  • Clonality
    Polyclonal
  • Formulation
    0.2 μm filtered solution in PBS with 5% trehalose
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    ELISA: 0.1-0.2 μg/mL

    This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse CDH5. The detection limit for Mouse CDH5 is approximately 0.00975 ng/well.

  • Validations
  • Background
    Cadherins (Calcium dependent adhesion molecules) are a class of transmembrane proteins. Cadherin-5, also known as VE-cadherin, CDH5 and CD144, an endothelial specific cell-cell adhesion molecule, plays a pivotal role in the formation, maturation and remodeling of the vascular wall. VE-Cadherin is widely considered to be specific for vascular endothelia in which it is either the sole or the predominant cadherin, often co-existing with N-cadherin. This specificity of VE-cadherin for vascular endothelial cells is important not only in blood and lymph vessel biology and medicine, but also for cell-type-based diagnoses, notably those of metastatic tumors. As a classical cadherin, VE-Cadherin links endothelial cells together by homophilic interactions mediated by its extracellular part and associates intracellularly with the actin cytoskeleton via catenins. Mechanisms that regulate VE-cadherin-mediated adhesion are important for the control of vascular permeability and leukocyte extravasation. In addition to its adhesive functions, VE-Cadherin regulates various cellular processes such as cell proliferation and apoptosis and modulates vascular endothelial growth factor receptor functions. Consequently, VE-cadherin is essential during embryonic angiogenesis.
  • References
    • Taveau JC, et al. (2008) Structure of artificial and natural VE-cadherin-based adherens junctions. Biochem Soc Trans. 36(Pt 2): 189-93.
    • Vestweber D. (2008) VE-cadherin: the major endothelial adhesion molecule controlling cellular junctions and blood vessel formation. Arterioscler Thromb Vasc Biol. 28(2): 223-32.
    • Gavard J. (2009) Breaking the VE-cadherin bonds. FEBS Lett. 583(1): 1-6.
    • Vestweber D, et al. (2009) Cell adhesion dynamics at endothelial junctions: VE-cadherin as a major player. Trends Cell Biol. 19(1): 8-15.
    • Boda-Heggemann J, et al. (2009) Beyond vessels: occurrence and regional clustering of vascular endothelial (VE-)cadherin-containing junctions in non-endothelial cells. Cell Tissue Res. 335(1): 49-65.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"