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  • Anti-succinyllysine Antibody

Anti-succinyllysine Antibody

Cat.#: 106768

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Special Price 296.8 USD

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Product Information

  • Product Name
    Anti-succinyllysine Antibody
  • Documents
  • Description
    Rabbit polyclonal Anti-succinyllysine Antibody
  • Tested applications
    ELISA, WB, IF, IP
  • Species reactivity
    Anti-succinyllysine antibody detects proteins post-translationally modified by lysine succinylation. The antibody recognizes succinyl lysine in a wide range of sequence contexts. The antibody has been shown to have more than 500 times selectivity against acetylated BSA and unmodified BSA.
  • Isotype
    Rabbit IgG
  • Preparation
    The rabbit-derived pan lysine succinylated antibody is purified by succinyl-lysine agarose affinity chromatography. It specifically recognizes proteins with lysine succinylated residues but not the acetyllysine or non-modified lysine residues. Besides common applications in Western blotting, immunoprecipitation and immunofluorescence, the antibody has been well utilized for proteomic screening to lysine succinylated substrates from protease-digested proteins both in prokaryotic and eukaryotic cells.
  • Clonality
    Polyclonal
  • Formulation
    Antibody is supplied in PBS with 50% glycerol and 0.01% sodium azide.
  • Storage instructions
    Store product at -20 ℃. Avoid repeated freeze / thaw. Stable for 12 months from date of receipt.
  • Applications

    Recommended antibody dilution: WB: 1:1000; IF: 1:500; IP: 1:200

    Important:For Western blotting, incubate membrane with diluted antibody in 5% BSA, 1 x TBS, 0.1% Tween-20 at 4 degree centigrade; with gentle shaking, overnight.

    Use at an assay dependent concentration. Optimal dilutions/concentrations should be determined by the end user. Not yet tested in other applications.

  • Validations

  • Background
    Lysine succinylation is a recently identified novel Protein Post-translational Modification. Lysine succinylation is evolutionarily conserved and abundantly present in proteins in both eukaryotic and eukaryotic cells, suggesting its roles in regulating cellular physiology. This antibody will facilitate studies of lysine succinylation biology by identifying its substrates and studying its function.
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"