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  • Anti-SIRP alpha/CD172a antibody

Anti-SIRP alpha/CD172a antibody

Cat.#: 104874

Special Price 145.0 USD

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Product Information

  • Product Name
    Anti-SIRP alpha/CD172a antibody
  • Documents
  • Description
    Rabbit polyclonal to SIRP alpha/CD172a
  • Tested applications
  • Species reactivity
    Mouse SIRP alpha / CD172a
  • Alternative names
    p84 antibody; AI835480 antibody; Bit antibody; BIT antibody; CD172a antibody; CD172A antibody; MFR antibody; MYD-1 antibody; P84 antibody; P84 antibody; Ptpns1 antibody; PTPNS1 antibody; RP23-37B4.2 antibody; SHP-1 antibody; SHPS1 antibody; SHPS-1 antibody; SIRP antibody; SIRP antibody; SIRP alpha antibody; SIRP alpha antibody; SHP-1 antibody; Bit antibody; SIRP antibody; CD172a antibody; Ptpns1 antibody; SHPS-1 antibody; AI835480 antibody; BIT antibody; MFR antibody; P84 antibody; SIRP antibody; MYD-1 antibody; SHPS1 antibody; CD172A antibody; PTPNS1 antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    Produced in rabbits immunized with purified, recombinant Mouse SIRP alpha / CD172a (rh SIRP alpha / CD172a; BAA20376.1; Met1-Asn373). SIRP alpha / CD172a specific IgG was purified by Mouse SIRP alpha / CD172a affinity chromatography.
  • Clonality
  • Formulation
    0.2 μm filtered solution in PBS
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    ELISA: 0.1-0.2 μg/mL

    This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse SIRP alpha / CD172a. The detection limit for Mouse SIRP alpha / CD172a is 0.00975 ng/well.

  • Validations
  • Background
    Tyrosine-protein phosphatase non-receptor type substrate 1, also known as SHP substrate 1, Inhibitory receptor SHPS-1, Brain Ig-like molecule with tyrosine-based activation motifs, Macrophage fusion receptor, CD172 antigen-like family member A, SIRPA and CD172a, is a single-pass type I membrane protein which contains two Ig-like C1-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. SIRPA is ubiquitously expressed. It is highly expressed in brain and detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas. It is also detected on myeloid cells, but not T-cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRPA acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. It may play a key role in intracellular signaling during synaptogenesis and in synaptic function. SIRPA is involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. It mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation.
  • References
    • Timms JF. et al., 1999, Curr Biol. 9: 927-30.
    • Stofega MR. et al., 2000, J Biol Chem. 275: 28222-9.
    • Liu T. et al., 2005, J Proteome Res. 4: 2070-80.
    • Wolf-Yadlin A. et al., 2007, Proc Natl Acad Sci. 104: 5860-5.