Anti-Semaphorin 4A/SEMA4A/Semaphorin B antibody
Rabbit polyclonal to Semaphorin 4A/SEMA4A/Semaphorin B
ELISA, WB, IP
Human Semaphorin 4A / SEMA4A / Semaphorin B
AI132332 antibody; CORD10 antibody; FLJ12287 antibody; RP11-54H19.2 antibody; RP35 antibody; sema B antibody; sema B antibody; Sema4a antibody; Semab antibody; Semaphorin 4A antibody; Semaphorin 4A antibody; semaphorin-B antibody; semaphorin-B antibody; SemB antibody; SEMB antibody; SEMA4A antibody; SEMAB antibody; SemB antibody; Semab antibody; AI132332 antibody; RP35 antibody; SEMB antibody; SEMAB antibody; CORD10 antibody
Produced in rabbits immunized with purified, recombinant Human Semaphorin 4A / SEMA4A / Semaphorin B (rh Semaphorin 4A / SEMA4A / Semaphorin B; NP_071762.2; Met 1-His 683). Semaphorin 4A / SEMA4A / Semaphorin B specific IgG was purified by Human Semaphorin 4A / SEMA4A / Semaphorin B affinity chromatography.
0.2 μm filtered solution in PBS with 5% trehalose
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
WB: 10-20 μg/mL
ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human SEMA4A. The detection limit for Human SEMA4A is approximately 0.00245 ng/well.
IP: 1-4 μg/mg of lysate
Semaphorin 4A / SEMA4A / Semaphorin B Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot
Semaphorin 4A / SEMA4A / Semaphorin B Antibody, Rabbit PAb, Antigen Affinity Purified
Semaphorin-4A, also known as Semaphorin-B, SEMA4A, Sema B and SEMAB, is a single-pass type I membrane protein which belongs to the semaphorin family. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. Semaphorin-4A / SEMA4A contains one Ig-like C2-type (immunoglobulin-like) domain, one PSI domain and one Sema domain. Defects in SEMA4A are the cause of retinitis pigmentosa type 35 (RP35) which leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Defects in SEMA4A are also the cause of cone-rod dystrophy type 10 (CORD10) which are inherited retinal dystrophies belonging to the group of pigmentary retinopathies. CORDs are characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration.Semaphorins are secreted, transmembrane, and GPI-linked proteins, defined by cysteine-rich semaphorin protein domains, that have important roles in a variety of tissues. Humans have 20 semaphorins, Drosophila has five, and two are known from DNA viruses. Semaphorins are found in nematodes and crustaceans but not in non-animals. They are grouped into eight classes on the basis of phylogenetic tree analyses and the presence of additional protein motifs. Semaphorins have been implicated in diverse developmental processes such as axon guidance during nervous system development and regulation of cell migration.
- Clark H.F., et al., 2003, Genome Res. 13: 2265-2270.
- Ota T., et al., 2004,Nat. Genet. 36: 40-45.
- Neufeld, G. et al., 2005, Front Biosci. 10 : 751-60.
- Fiore,R. et al., 2005, Mol Cell Biol. 25 (6):2310-9.
- Abid A., et al., 2006, J. Med. Genet. 43:378-381.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"