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  • Anti-SCF/C-kit ligand antibody

Anti-SCF/C-kit ligand antibody

Cat.#: 105068

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Product Information

  • Product Name
    Anti-SCF/C-kit ligand antibody
  • Documents
  • Description
    Rabbit polyclonal to SCF/C-kit ligand
  • Tested applications
    ELISA
  • Species reactivity
    Human SCF / C-kit ligand
  • Alternative names
    MGF antibody; C-kit ligand antibody; C-kit ligand antibody; Clo antibody; Con antibody; contrasted antibody; DKFZp686F2250 antibody; FPH2 antibody; Gb antibody; Kitl antibody; Kitl antibody; Kitlg antibody; KITLG antibody; KL-1 antibody; Mgf antibody; SCF antibody; SCF antibody; SF antibody; SF antibody; SHEP7 antibody; Sl antibody; SLF antibody; Steel antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    Produced in rabbits immunized with purified, recombinant Human SCF / C-kit ligand (rh KITLG; P21583-1; Met1-Ala189). Total IgG was purified by Protein A affinity chromatography.
  • Clonality
    Polyclonal
  • Formulation
    0.2 μm filtered solution in PBS
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
  • Applications

    ELISA: 0.5-1 μg/mL

    This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Human SCF / C-kit ligand. The detection limit for Human SCF / C-kit ligand is <0.039 ng/well.

  • Validations
  • Background
    Similar to Kit ligand precursor (C-kit ligand) , also known as Stem cell factor (SCF), Mast cell growth factor (MGF) or Hematopoietic growth factor KL. SCF/C-kit ligand is the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis. SCF/C-kit ligand stimulates the proliferation of mast cells. This protein is able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. It may act synergistically with other cytokines, probably interleukins SCF/C-kit ligand is the ligand for the tyrosine kinase receptor c-kit, which is expressed on both primitive and mature hematopoietic progenitor cells. In vitro, SCF/C-kit ligand synergizes with other growth factors, such as granulocyte colony-stimulating factor (G-CSF), granulocyte macrophage- colony- stimulating factor, and interleukin-3 to stimulate the proliferation and differentiation of cells of the lymphoid, myeloid, erythroid, and megakaryocytic lineages. In vivo, SCF/C-kit also synergizes with other growth factors and has been shown to enhance the mobilization of peripheral blood progenitor cells in combination with G-CSF. In phase I/II clinical studies administration of the combination of SCF and G-CSF resulted in a two- to threefold increase in cells that express the CD34 antigen compared with G-CSF alone.
  • References
    • McNiece IK, et al. (1995) Stem cell factor. J Leukoc Biol. 58(1): 14-22.
    • Besmer P, et al. (1993) The kit-ligand (steel factor) and its receptor c-kit/W: pleiotropic roles in gametogenesis and melanogenesis. Dev Suppl. 1993:125-37.
    • Mekori YA, et al. (1993) IL-3-dependent murine mast cells undergo apoptosis on removal of IL-3. Prevention of apoptosis by c-kit ligand. J Immunol. 151(7): 3775-84.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"