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  • Anti-PD-L1/B7-H1/CD274 antibody
  • Anti-PD-L1/B7-H1/CD274 antibody

Anti-PD-L1/B7-H1/CD274 antibody

Cat.#: 100194

Special Price 145.0 USD

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Product Information

  • Product Name
    Anti-PD-L1/B7-H1/CD274 antibody
  • Documents
  • Description
    Rabbit polyclonal to PD-L1/B7-H1/CD274
  • Tested applications
    ELISA, IHC-P
  • Species reactivity
    Human PD-L1 / B7-H1 / CD274
  • Alternative names
    B7-H antibody; B7H1 antibody; B7h1 antibody; CD274 antibody; Cd274 A530045L16Rik antibody; MGC142294 antibody; MGC142296 antibody; Pdcd1l1 antibody; PDCD1L1 antibody; Pdcd1lg1 antibody; PDCD1LG1 antibody; PDL1 antibody; Pdl1 antibody; PD-L1 antibody; PD-L1 antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    Produced in rabbits immunized with purified, recombinant Human PD-L1 / B7-H1 / CD274 (rh PD-L1 / B7-H1 / CD274; NP_054862.1; Met1-Thr239). PD-L1 / B7-H1 / CD274 specific IgG was purified by Human PD-L1 / B7-H1 / CD274 affinity chromatography.
  • Clonality
    Polyclonal
  • Formulation
    0.2 μm filtered solution in PBS
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    ELISA: 0.1-0.2 μg/ml

    This antibody can be used at 0.1-0.2 μg/ml with the appropriate secondary reagents to detect Human PD-L1 / B7-H1 / CD274.

    IHC-P: 0.1-2 μg/mL

  • Validations

    PD-L1 / B7-H1 / CD274 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry

    PD-L1 / B7-H1 / CD274 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry

    Immunochemical staining of human B7-H1 in human tonsil with rabbit polyclonal antibody (0.5 µg/mL, formalin-fixed paraffin embedded sections).

    PD-L1 / B7-H1 / CD274 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry

    PD-L1 / B7-H1 / CD274 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry

    Immunochemical staining of human B7-H1 in human placenta with rabbit polyclonal antibody (0.5 µg/mL, formalin-fixed paraffin embedded sections).

  • Background
    Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. PD-L1/B7-H1 is a member of the growing B7 family of immune molecules and this protein contains one V-like and one C-like Ig domain within the extracellular domain, and together with PD-L2, are two ligands for PD1 which belongs to the CD28/CTLA4 family expressed on activated lymphoid cells. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.
  • References
    • Iwai Y, et al. (2002) Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc Natl Acad Sci U S A. 99(19): 12293-7.
    • Ghebeh H, et al. (2006) The B7-H1 (PD-L1) T lymphocyte-inhibitory molecule is expressed in breast cancer patients with infiltrating ductal carcinoma: correlation with important high-risk prognostic factors. Neoplasia. 8(3): 190-8.
    • Salih HR, et al. (2006) The role of leukemia-derived B7-H1 (PD-L1) in tumor-T-cell interactions in humans. Exp Hematol. 34(7): 888-94.
    • Wilcox RA, et al. (2009) B7-H1 (PD-L1, CD274) suppresses host immunity in T-cell lymphoproliferative disorders. Blood. 114(10): 2149-58.
    • Ruggiero A, et al. (2009) Crystal structure of PD-L1, a ribosome inactivating protein from Phytolacca dioica L. leaves with the property to induce DNA cleavage. Biopolymers. 91(12): 1135-42.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"