Anti-PA28A / PSME1 antibody
Rabbit polyclonal to PA28A / PSME1
Human PA28A / PSME1
proteasome (prosome antibody; macropain) activator subunit 1 (PA28 alpha) antibody; PSME1 antibody; IFI5111 antibody; PA28A antibody; PA28alpha antibody; REGalpha antibody; 11S regulator complex alpha subunit antibody; 11S regulator complex subunit alpha antibody; 29-kD MCP activator subunit antibody; IGUP I-5111 antibody; REG-alpha antibody; activator of multicatalytic protease subunit 1 antibody; interferon gamma up-regulated I-5111 protein antibody; interferon-gamma IEF SSP 5111 antibody; interferon-gamma-inducible protein 5111 antibody; proteasome activator 28 subunit alpha antibody; proteasome activator complex subunit 1 antibody; proteasome activator subunit-1 antibody; proteasome (prosome antibody; macropain) 28 subunit antibody; alpha antibody; Psme1 antibody; AW413925 antibody; PA28a antibody; 11S regulator complex subunit alpha antibody; PA28 alpha subunit antibody; PA28alpha antibody; REG-alpha antibody; activator of multicatalytic protease subunit 1 antibody; protease (prosome antibody; macropain) 28 subunit antibody; alpha antibody; proteasome activator 28 subunit alpha antibody; proteasome activator complex subunit 1 antibody; PA28A antibody; IFI5111 antibody; REGalpha antibody; PA28alpha antibody; PA28a antibody; AW413925 antibody
Produced in rabbits immunized with purified, recombinant Human PA28A / PSME1 (rh PSME1; Q06323; Met1-Tyr249). Total IgG was purified by Protein A affinity chromatography.
0.2 μm filtered solution in PBS
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
ELISA: 0.5-1 μg/mL
This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Human PA28A / PSME1. The detection limit for Human PA28A / PSME1 is <0.039 ng/well.
PA28A, also known as PSME1, is a subunit of proteasome. The 26S proteasome multicatalytic proteinase complex has a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. PSME1 gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring.
- Honore B. et al., 1994, Eur J Biochem 218 (2): 421-30.
- Wilkinson. et al., 2003, J. Biochem. (Germany) 270 (11): 2459-66.
- Rual Jean-François. et al., 2005, Nature. (England) 437 (7062): 1173-8.
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