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  • Anti-IL-28B/IFN-lambda-3 antibody

Anti-IL-28B/IFN-lambda-3 antibody

Cat.#: 100505


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Product Information

  • Product Name
    Anti-IL-28B/IFN-lambda-3 antibody
  • Documents
  • Description
    Rabbit monoclonal to IL-28B/IFN-lambda-3
  • Tested applications
  • Species reactivity
    Human IL-28B / IFN-lambda-3
  • Alternative names
    INF-alpha antibody; IL28B antibody; IL28C antibody; IL-28B antibody; Il28 antibody; IFL-1 antibody; Il28b antibody; IL-28B antibody; INF-alpha antibody; INF-lambda antibody; Il28 antibody; IL28C antibody; INF-lambda antibody; IFL-1 antibody; IFNL3 antibody; IFN-lambda-3 antibody; IFN-lambda-3 antibody; Il28b antibody; IL28B antibody; IL-28B antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained from a rabbit immunized with purified, recombinant Human IL-28B / IFN-lambda-3 (rh IL-28B / IFN-lambda-3; NP_742151.2; Met1-Val196).
  • Clonality
  • Formulation
    0.2 μm filtered solution in PBS with 5% trehalose
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    ELISA: 0.1-0.2 μg/mL

    This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human IL28B. The detection limit for Human IL28B is approximately 0.039 ng/well.

  • Validations
  • Background
    Interleukin-28B (IL-28B) also known as Interferon lambda-3 and IFN-lambda-3, belongs to the type III interferon family of cytokines and are highly similar to IL-29. IL-28B belongs to the newly described interferon lambda (IFNλ) family of cytokines. IL-28B is a cytokine with immunomodulatory activity. It functions in Up-regulating MHC class I antigen expression. IL-28B displays potent antiviral activity and antitumor activity. This cytokine serves as ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway. IL-28B, like IL-12, is capable of robustly enhancing adaptive immunity. Moreover, we describe for the first time how IL-28B reduces regulatory T-cell populations during DNA vaccination, whereas IL-12 increases this cellular subset. We also show that IL-28B, unlike IL-12, is able to increase the percentage of splenic CD8+ T cells in vaccinated animals, and that these cells are more granular and have higher antigen-specific cytolytic degranulation compared with cells taken from animals that received IL-12 as an adjuvant.
  • References
    • Ge D, et al.. (2009) Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature. 461(7262): 399-401.
    • Morrow MP, et al.. (2009) Comparative ability of IL-12 and IL-28B to regulate Treg populations and enhance adaptive cellular immunity. Blood. 113(23): 5868-77.
    • Sheppard P, et al.. (2003) IL-28, IL-29 and their class II cytokine receptor IL-28R. Nat Immunol. 4(1): 63-8.