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  • Anti-IL-1RA/IL1RN antibody

Anti-IL-1RA/IL1RN antibody

Cat.#: 104817

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Product Information

  • Product Name
    Anti-IL-1RA/IL1RN antibody
  • Documents
  • Description
    Rabbit polyclonal to IL-1RA/IL1RN
  • Tested applications
  • Species reactivity
    Human IL-1RA / IL1RN
  • Alternative names
    DIRA antibody; F630041P17Rik antibody; ICIL-1RA antibody; IL1F3 antibody; IL-1RA antibody; IL-1ra antibody; IL-1ra3 antibody; IL1RN antibody; Il1rn antibody; IRAP antibody; MGC10430 antibody; MVCD4 antibody; RP23-218B17.2 antibody; IL1RA antibody; DIRA antibody; IRAP antibody; IL1F3 antibody; IL1RA antibody; MVCD4 antibody; IL-1RN antibody; IL-1ra antibody; IL-1ra3 antibody; ICIL-1RA antibody; IL-1ra antibody; F630041P17Rik antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    Produced in rabbits immunized with purified, recombinant Human IL-1RA / IL1RN (rh IL1RN; NP_776214.1; Arg26-Glu177). Total IgG was purified by Protein A affinity chromatography.
  • Clonality
  • Formulation
    0.2 μm filtered solution in PBS
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
  • Applications

    ELISA: 0.5-1 μg/mL

    This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Human IL-1RA / IL1RN. The detection limit for Human IL-1RA / IL1RN is <0.039 ng/well.

  • Validations
  • Background
    Interleukin-1 receptor antagonist (IL-1RA) also known as IL1RN is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. A polymorphism of this protein encoding gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. IL-1RA/IL1RN may inhibit the activity of IL-1 by binding to its receptor and it has no IL-1 like activity. Genetic variation in IL-1RA/IL1RN is associated with susceptibility to microvascular complications of diabetes type 4 (MVCD4). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Defects in IL-1RA/IL1RN are the cause of interleukin 1 receptor antagonist deficiency (DIRA) which is also known as deficiency of interleukin 1 receptor antagonist. Autoinflammatory diseases manifest inflammation without evidence of infection, high-titer autoantibodies, or autoreactive T-cells. DIRA is a rare, autosomal recessive, genetic autoinflammatory disease that results in sterile multifocal osteomyelitis, and pustulosis from birth.
  • References
    • Langdahl BL, et al. (2000) Osteoporotic fractures are associated with an 86-base pair repeat polymorphism in the interleukin-1--receptor antagonist gene but not with polymorphisms in the interleukin-1beta gene. J Bone Miner. 15 (3): 402-14.
    • El-Omar EM, et al. (2000) Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature. 404 (6776): 398-402.
    • Steinkasserer A, et al. (1992) The human IL-1 receptor antagonist gene (IL1RN) maps to chromosome 2q14-q21, in the region of the IL-1 alpha and IL-1 beta loci. Genomics. 13 (3): 654-7.