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  • Anti-IL-17R/IL-17RA (CD217) antibody

Anti-IL-17R/IL-17RA (CD217) antibody

Cat.#: 105093

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Product Information

  • Product Name
    Anti-IL-17R/IL-17RA (CD217) antibody
  • Documents
  • Description
    Rabbit polyclonal to IL-17R/IL-17RA (CD217)
  • Tested applications
  • Species reactivity
    Human IL-17R / IL-17RA (CD217)
  • Alternative names
    Cdw217 antibody; AW538159 antibody; CD217 antibody; CDw217 antibody; hIL-17R antibody; Il17r antibody; IL17R antibody; IL-17R antibody; Il17ra antibody; IL17RA antibody; MGC10262 antibody; VDw217 antibody; Cdw217 antibody; Il17r antibody; VDw217 antibody; AW538159 antibody; CD217 antibody; IL17R antibody; CANDF5 antibody; CDw217 antibody; IL-17RA antibody; hIL-17R antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    Produced in rabbits immunized with purified, recombinant Human IL-17R / IL-17RA (CD217) (rh IL-17R / IL-17RA (CD217); NP_055154.3; Met1-Trp320). IL-17R / IL-17RA (CD217) specific IgG was purified by Human IL-17R / IL-17RA (CD217) affinity chromatography.
  • Clonality
  • Formulation
    0.2 μm filtered solution in PBS
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    ELISA: 0.1-0.2 μg/mL

    This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human IL-17R / IL-17RA (CD217). The detection limit for Human IL-17R / IL-17RA (CD217) is < 0.039 ng/well.

  • Validations
  • Background
    Interleukin-17 receptor (IL-17R), also known as Interleukin-17 receptor A (IL-17RA) and CD217 antigen (CD217), is a cytokine receptor which binds interleukin 17. IL-17R/IL-17RA (CD217) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17R/IL-17RA (CD217) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Defects in IL-17R/IL-17RA (CD217) are the cause of familial candidiasis type 5 (CANDF5). CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.
  • References
    • Gaffen SL. (2009) Structure and signalling in the IL-17 receptor family. Nat Rev Immunol. 9 (8): 556-67.
    • Johansen C, et al.. (2009) Characterization of the interleukin-17 isoforms and receptors in lesional psoriatic skin. Br J Dermatol. 160 (2): 319-24.
    • Yao Z, et al.. (1997) Molecular characterization of the human interleukin (IL)-17 receptor. Cytokine 9 (11): 794-800.