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  • Anti-FCRL1/FCRH1 antibody

Anti-FCRL1/FCRH1 antibody

Cat.#: 104999

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Product Information

  • Product Name
    Anti-FCRL1/FCRH1 antibody
  • Documents
  • Description
    Rabbit polyclonal to FCRL1/FCRH1
  • Tested applications
    ELISA
  • Species reactivity
    Human FCRL1 / FCRH1
  • Alternative names
    FCRH1 antibody; IFGP1 antibody; IRTA5 antibody; CD307a antibody; Bxmh1 antibody; Fcrh1 antibody; Ifgp1 antibody; Bxmas1 antibody; Bxmh1b antibody; Fcrh1l antibody; Fcrh1s antibody; A230020G22Rik antibody; DKFZp667O1421 antibody; Fcrh1 antibody; FCRH1 antibody; Fcrh1l antibody; Fcrh1s antibody; Fcrl1 antibody; FCRL1 antibody; Ifgp1 antibody; IRTA5 antibody; A230020G22Rik antibody; Bxmas1 antibody; Bxmh1 antibody; Bxmh1b antibody; IFGP1 antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    Produced in rabbits immunized with purified, recombinant Human FCRL1 / FCRH1 (rh FCRL1; NP_001890.1; Met1-Asn303). Total IgG was purified by Protein A affinity chromatography.
  • Clonality
    Polyclonal
  • Formulation
    0.2 μm filtered solution in PBS
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
  • Applications

    ELISA: 0.5-1 μg/mL

    This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Human FCRL1 / FCRH1. The detection limit for Human FCRL1 / FCRH1 is <0.039 ng/well.

  • Validations
  • Background
    Fc receptor-like protein 1, also known as FcR-like protein 1, Fc receptor homolog 1, IFGP family protein 1, Immune receptor translocation-associated protein 5 and FCRL1, is a single-pass type I  membrane protein which contains three Ig-like C2-type (immunoglobulin-like) domains. It is a cell-surface membrane protein belonging to FCRL family and is preferentially expressed on B cells. FCRL1 is primarily expressed in secondary lymphoid tissues by mature subsets of B cells. It is detected in spleen, lymph node, heart, skeletal muscle, kidney, liver and placenta. FCRL1 is specifically expressed by mature B lineage cells with higher expression in naive versus memory B cells (at protein level). Human Fc receptor-like molecules (FCRL1, FCRL2, FCRL3, FCRL4, FCRL5) have tyrosine-based immunoregulatory potential and are expressed by B-lineage subpopulations. FCRL1 may function as an activating coreceptor in B cells. It may also function in B cells activation and differentiation.
  • References
    • Du X. et al., 2008, Blood. 111 (1): 338-43.
    • Kazemi T. et al., 2008, Int J Cancer. 123 (9): 2113-9.
    • Baranov K. et al., 2008, J Immunol Methods. 332 (1-2): 73-81.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"