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  • Anti-Ephrin-A5/EFNA5 antibody

Anti-Ephrin-A5/EFNA5 antibody

Cat.#: 102009

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Product Information

  • Product Name
    Anti-Ephrin-A5/EFNA5 antibody
  • Documents
  • Description
    Rabbit polyclonal to Ephrin-A5/EFNA5
  • Tested applications
  • Species reactivity
    Human EphrinA5 / EFNA5 / EPLG7
  • Alternative names
    AL-1 antibody; Epl7 antibody; RAGS antibody; EFL-5 antibody; LERK-7 antibody; AV158822 antibody; Ephrin-A5 antibody; AF1 antibody; EFL5 antibody; RAGS antibody; EPLG7 antibody; GLC1M antibody; LERK7 antibody; AF1 antibody; AL-1 antibody; AV158822 antibody; EFL5 antibody; EFL-5 antibody; Efna5 antibody; EFNA5 antibody; Ephrin-A5 antibody; Ephrin-A5 antibody; Epl7 antibody; EPLG7 antibody; GLC1M antibody; LERK7 antibody; LERK-7 antibody; RAGS antibody; RAGS antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    Produced in rabbits immunized with purified, recombinant Human EphrinA5 (rhEphrinA5; NP_001953.1; Met 1-Asn 203). EphrinA5 specific IgG was purified by human EphrinA5 affinity chromatography.
  • Clonality
  • Formulation
    0.2 μm filtered solution in PBS with 5% trehalose
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    ELISA: 0.1-0.2 μg/mL

    This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human EphrinA5. The detection limit for Human EphrinA5 is 0.00245 ng/well.

  • Validations
  • Background
    Ephrin-A5 also known as EFNA5, is a member of the Ephrin family. The Eph family receptor interacting proteins (ephrins) are a family of proteins that serve as the ligands of the Eph receptor, which compose the largest known subfamily of receptor protein-tyrosine kinases (RTKs). Ephrin subclasses are further distinguished by their mode of attachment to the plasma membrane: ephrin-A ligands bind EphA receptors and are anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) linkage, whereas ephrin-B ligands bind EphB receptors and are anchored via a transmembrane domain. Ephrin-A5/EFNA5 may function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Ephrin-A5/EFNA5 also serves as a cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion.
  • References
    • Frisén J, et al. (1998) Ephrin-A5 (AL-1/RAGS) is essential for proper retinal axon guidance and topographic mapping in the mammalian visual system. Neuron. 20(2): 235-43.
    • Feldheim DA, et al. (2000) Genetic analysis of ephrin-A2 and ephrin-A5 shows their requirement in multiple aspects of retinocollicular mapping. Neuron. 25(3): 563-74.
    • Wahl S, et al. (2000) Ephrin-A5 induces collapse of growth cones by activating Rho and Rho kinase. J Cell Biol. 149(2): 263-70.