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  • Anti-EGFR/HER1/ErbB1 antibody

Anti-EGFR/HER1/ErbB1 antibody

Cat.#: 103833

Special Price 161.3 USD

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Product Information

  • Product Name
    Anti-EGFR/HER1/ErbB1 antibody
  • Documents
  • Description
    Rabbit monoclonal to EGFR/HER1/ErbB1
  • Tested applications
    FCM
  • Species reactivity
    Human EGFR / HER1 / ErbB1
  • Alternative names
    ERBB antibody; HER1 antibody; mENA antibody; ERBB1 antibody; PIG61 antibody; NISBD2 antibody; Wa5 antibody; wa2 antibody; Erbb antibody; Errp antibody; wa-2 antibody; Errb1 antibody; AI552599 antibody; 9030024J15Rik antibody; 9030024J15Rik antibody; AI552599 antibody; EGFR antibody; Egfr antibody; Egfr antibody; ERBB antibody; Erbb antibody; ERBB1 antibody; ERBB1 antibody; ErbB-1 antibody; Errp antibody; Errp antibody; HER1 antibody; mENA antibody; PIG61 antibody; RP23-295E4.1 antibody; wa2 antibody; wa-2 antibody; Wa5 antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained from a rabbit immunized with purified, recombinant Human EGFR / HER1 / ErbB1 (rh EGFR / HER1 / ErbB1; NP_005219; Met 1-Ser 645) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
  • Clonality
    Monoclonal
  • Formulation
    Aqueous solution containing 0.5% BSA and 0.09% sodium azide
  • Storage instructions
    This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
    Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
  • Applications
    FCM
  • Validations

    EGFR / HER1 / ErbB1 Antibody (FITC), Rabbit MAb, Flow cytometric analysis

    EGFR / HER1 / ErbB1 Antibody (FITC), Rabbit MAb, Flow cytometric analysis

    Profile of anti-EGFR reactivity on A431 cells analyzed by flow cytometry.

  • Background
    As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.
  • References
    • Schlessinger, J. (2000) Cell signaling by receptor tyrosine kinases. Cell 103(2): 211-25.
    • Giaccone, G. (2005) HER1/EGFR-targeted agents: predicting the future for patients with unpredictable outcomes to therapy. Ann. Oncol. 16(4): 538-48.
    • Yarden, Y., et al. (2001) Untangling the ErbB signalling network. Nat. Rev. Mol. Cell. Biol. 2(2): 127-37.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"