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  • Anti-DKK-1 antibody

Anti-DKK-1 antibody

Cat.#: 100691

Special Price 290.3 USD

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Product Information

  • Product Name
    Anti-DKK-1 antibody
  • Documents
  • Description
    Rabbit monoclonal to DKK-1
  • Tested applications
    B/N
  • Species reactivity
    Human DKK-1
    Has cross-reactivity with Rhesus DKK-1 / Dkk1 (11089-K08H) in ELISA assay
  • Alternative names
    S antibody; SK antibody; DKK-1 antibody; mdkk-1 antibody; Dickkopf 1 antibody; DKK1 antibody; DKK-1 antibody; hDKK 1 antibody; SK antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained from a rabbit immunized with purified, recombinant Human DKK-1 (rh DKK-1; NP_036374.1; Met2-His266) and was produced using recombinant antibody technology.
  • Clonality
    Monoclonal
  • Formulation
    0.2 μm filtered solution in Histidine and Arginine buffer containing 120mM NaCl, 0.02% Tween 80, pH6.0
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications
    Neutralization - The neutralization activity of antibody is Measured by its ability to inhibit Wnt3a-induced alkaline phosphatase production by C3H10T1/2 cells. The Neutralization titer (IC50) is typically 0.1-0.4 μg/ml in the presence of 40 ng/mL Mouse Wnt-3a and 10 µg/mL DKK1.
  • Validations
  • Background
    Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 and promote the internalization of LRP5/6. Dickkopf related protein 1 (DKK-1) was initially identified as an inducer of head formation in Xenopus embryos. DKK-1 protein modulates Wnt signaling pathway during embryonic development. Increased levels of DKK-1 are found in the majority of lung cancers, esophageal squamous cell carcinomas, and hormone-resistant breast cancers, while DKK-1 expression is decreased in malignant melanoma and colorectal cancers.
  • References
    • Horwitz EM. (2004) Dkk-1-mediated expansion of adult stem cells. Trends Biotechnol. 22(8): 386-8.
    • Jiang T, et al. (2009) Clinical significance of serum DKK-1 in patients with gynecological cancer. Int J Gynecol Cancer. 19(7): 1177-81.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"