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  • Anti-CTLA-4/CD152 antibody

Anti-CTLA-4/CD152 antibody

Cat.#: 105693

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Product Information

  • Product Name
    Anti-CTLA-4/CD152 antibody
  • Documents
  • Description
    Rabbit polyclonal to CTLA-4/CD152
  • Tested applications
  • Species reactivity
    Canine CTLA-4 / CD152
  • Alternative names
    ICOS antibody; CD antibody; CD152 antibody; Cd152 antibody; CELIAC3 antibody; CH29-120A16.2 antibody; Ctla4 antibody; CTLA4 antibody; CTLA-4 antibody; Ctla-4 antibody; GRD4 antibody; GSE antibody; IDDM12 antibody; Ly-56 antibody; CD antibody; GSE antibody; GRD4 antibody; ALPS5 antibody; CD152 antibody; CTLA-4 antibody; IDDM12 antibody; CELIAC3 antibody; Cd152 antibody; Ly-56 antibody; Ctla-4 antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    Produced in rabbits immunized with purified, recombinant Canine CTLA-4 / CD152 (rh CTLA-4 / CD152; NP_001003106.1; Met1-Asp161). CTLA-4 / CD152 specific IgG was purified by Canine CTLA-4 / CD152 affinity chromatography.
  • Clonality
  • Formulation
    0.2 μm filtered solution in PBS
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    ELISA: 0.1-0.2 μg/mL

    This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Canine CTLA-4 / CD152. The detection limit for Canine CTLA-4 / CD152 is < 0.039 ng/well.

  • Validations
  • Background
    Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family. The ligands or counterreceptors for these two proteins are the B7 family members, CD80 (B7-1) and CD86 (B7-2). CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their functions. CD152 or cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential receptor involved in the negative regulation of T cell activation. Because of its profound inhibitory role, CD152 has been considered a sound susceptible candidate in autoimmunity and a persuasive target for cancer immunotherapy. In particular, recent evidence suggests that CD152 is also important in the homeostasis and function of a population of suppressive cells, termed regulatory T cells (Treg).
  • References
    • Slavik JM, et al. (1999) CD28/CTLA-4 and CD80/CD86 families: signaling and function. Immunol Res. 19(1): 1-24.
    • Holmberg D, et al. (2005) CTLA-4 (CD152) and its involvement in autoimmune disease. Autoimmunity. 38(3): 225-33.
    • Chin LT, et al. (2008) Immune intervention with monoclonal antibodies targeting CD152 (CTLA-4) for autoimmune and malignant diseases. Chang Gung Med J. 31(1): 1-15.