NovoPro
Cart 2
  • Anti-CD89/FCAR antibody

Anti-CD89/FCAR antibody

Cat.#: 104443

Special Price 161.3 USD

Availability: In Stock
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    Anti-CD89/FCAR antibody
  • Documents
  • Description
    Mouse monoclonal to CD89/FCAR
  • Tested applications
    FCM
  • Species reactivity
    Human CD89 / FCAR
  • Alternative names
    CD89 antibody; FCAR antibody; XXbac-BPG230H20.5 antibody
  • Immunogen
  • Isotype
    Mouse IgG1
  • Preparation
    This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD89 / FCAR (rh CD89 / FCAR; NP_001991.1; Met 1-Asn 227) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
  • Clonality
    Monoclonal
  • Formulation
    Aqueous solution containing 0.5% BSA and 0.1% sodium azide
  • Storage instructions
    This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
    Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
  • Applications
    FCM
  • Validations

    CD89 / FCAR Antibody (FITC), Mouse MAb, Flow cytometric

    CD89 / FCAR Antibody (FITC), Mouse MAb, Flow cytometric

    Flow cytometric analysis of anti-human CD89 on human whole blood granulocytes. The fluorescence histograms were derived from events with the forward and side light-scatter characteristics of viable granulocytes.

  • Background
    FCAR, also called FcαRI or CD89, is a type I  transmembrane receptor for Fc region of IgA which is the most abundant immunoglobulin in mucosal areas but is only the second most common antibody isotype in serum. This receptor is present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, especially phagocytes located in mucosal areas. Upon ligand IgA binding, FcαRI associates with the FcR γ signaling molecule bearing the immunoreceptor tyrosine-based activation motif (ITAM) through a unique charge-based mechanism and triggers multiple cell-mediated immune responses. It has been reported that Fc RI is a dual-function receptor that can mediate both inflammatory and anti-inflammatory responses depending on the type of interaction with its ligand. Sustained aggregation of FCAR results in activation of target-cell functions such as antigen presentation and cytokine release. In contrast, Monomeric targeting with serum IgA or with a variety of anti-FcαRI Fab fragments triggers an inhibitory response and additionally induces apoptosis. FcαRI thus play an fundamental role in preventing tumor development and growth, as well as in controlling inflammation.
  • References
    • Maliszewski, C.R. et al., 1990, J. Exp. Med. 172: 1665-1672.
    • Launay, P. et al., 1999, J. Biol. Chem. 274: 7216-7225.
    • Monteiro, R.C. et al., 2003, Annu. Rev. Immunol. 21: 177-204.
    • Otten, M.A. et al., 2005, J. Immunol. 174: 5472-5480.
    • Pasquier, B. et al., 2005, Immunity. 22:31-42.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"