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  • Anti-CD89/FCAR antibody

Anti-CD89/FCAR antibody

Cat.#: 101951

Special Price 145.0 USD

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Product Information

  • Product Name
    Anti-CD89/FCAR antibody
  • Documents
  • Description
    Rabbit polyclonal to CD89/FCAR
  • Tested applications
    ELISA
  • Species reactivity
    Human CD89 / FCAR
  • Alternative names
    CD89 antibody; FCAR antibody; XXbac-BPG230H20.5 antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    Produced in rabbits immunized with purified, recombinant Human CD89 / FCAR (rh CD89; NP_001991.1; Met 1-Asn 227). CD89 specific IgG was purified by human CD89 affinity chromatography.
  • Clonality
    Polyclonal
  • Formulation
    0.2 μm filtered solution in PBS with 5% trehalose
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    ELISA: 0.5-1.0 μg/mL

    This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Human CD89. The detection limit for Human CD89 is 0.00245 ng/well.

  • Validations
  • Background
    FCAR, also called FcαRI or CD89, is a type I  transmembrane receptor for Fc region of IgA which is the most abundant immunoglobulin in mucosal areas but is only the second most common antibody isotype in serum. This receptor is present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, especially phagocytes located in mucosal areas. Upon ligand IgA binding, FcαRI associates with the FcR γ signaling molecule bearing the immunoreceptor tyrosine-based activation motif (ITAM) through a unique charge-based mechanism and triggers multiple cell-mediated immune responses. It has been reported that Fc RI is a dual-function receptor that can mediate both inflammatory and anti-inflammatory responses depending on the type of interaction with its ligand. Sustained aggregation of FCAR results in activation of target-cell functions such as antigen presentation and cytokine release. In contrast, Monomeric targeting with serum IgA or with a variety of anti-FcαRI Fab fragments triggers an inhibitory response and additionally induces apoptosis. FcαRI thus play an fundamental role in preventing tumor development and growth, as well as in controlling inflammation.
  • References
    • Maliszewski, C.R. et al., 1990, J. Exp. Med. 172: 1665-1672.
    • Launay, P. et al., 1999, J. Biol. Chem. 274: 7216-7225.
    • Monteiro, R.C. et al., 2003, Annu. Rev. Immunol. 21: 177-204.
    • Otten, M.A. et al., 2005, J. Immunol. 174: 5472-5480.
    • Pasquier, B. et al., 2005, Immunity. 22:31-42.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"