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  • Anti-CD80/B7-1 antibody

Anti-CD80/B7-1 antibody

Cat.#: 105663

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Product Information

  • Product Name
    Anti-CD80/B7-1 antibody
  • Documents
  • Description
    Rabbit monoclonal to CD80/B7-1
  • Tested applications
    ELISA, IHC-P
  • Species reactivity
    Human CD80 / B7-1
  • Alternative names
    B7 antibody; BB1 antibody; B7-1 antibody; B7.1 antibody; LAB7 antibody; CD28LG antibody; CD28LG1 antibody; B71 antibody; Ly53 antibody; TSA1 antibody; Cd28l antibody; Ly-53 antibody; MIC17 antibody; B7 antibody; B71 antibody; B7-1 antibody; Cd28l antibody; CD28LG antibody; CD28LG1 antibody; Cd80 antibody; CD80 antibody; LAB7 antibody; Ly53 antibody; Ly-53 antibody; MIC17 antibody; TSA1 antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained from a rabbit immunized with purified, recombinant Human CD80 / B7-1 (rh CD80 / B7-1; NP_005182.1; Met1-Asn242).
  • Clonality
    Monoclonal
  • Formulation
    0.2 μm filtered solution in PBS
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    ELISA: 0.1-0.2 μg/ml

    This antibody can be used at 0.1-0.2 μg/ml with the appropriate secondary reagents to detect Human CD80 / B7-1. The detection limit for Human IL-9 is 0.0098 ng/well.

    IHC-P: 10-30 μg/mL

  • Validations

    CD80 / B7-1 Antibody, Rabbit MAb, Immunohistochemistry

    CD80 / B7-1 Antibody, Rabbit MAb, Immunohistochemistry

    Immunochemical staining of human B7-1 in human tonsil with rabbit monoclonal antibody (15 µg/mL, formalin-fixed paraffin embedded sections).

  • Background
    The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. As costimulatory ligands, B7-1 which exists predominantly as dimer and the related protein B7-2, interact with the costimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus constitute one of the dominant pathways that regulate T cell activation and tolerance, cytokine production, and the generation of CTL. The B7/CD28/CTLA4 pathway has the ability to both positively and negatively regulate immune responses. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.
  • References
    • Greenfield EA, et al. (1998) CD28/B7 costimulation: a review. Crit Rev Immunol. 18(5): 389-418.
    • Zang X, et al. (2007) The B7 family and cancer therapy: costimulation and coinhibition. Clin Cancer Res. 13(18 Pt 1): 5271-9.
    • Mir MA, et al. (2008) Signaling through CD80: an approach for treating lymphomas. Expert Opin Ther Targets. 12(8): 969-79.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"