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  • Anti-CD112/Nectin-2/PVRL2 antibody

Anti-CD112/Nectin-2/PVRL2 antibody

Cat.#: 102795

Special Price 161.3 USD

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Product Information

  • Product Name
    Anti-CD112/Nectin-2/PVRL2 antibody
  • Documents
  • Description
    Rabbit monoclonal to CD112/Nectin-2/PVRL2
  • Tested applications
    FCM
  • Species reactivity
    Human CD112 / Nectin-2
  • Alternative names
    HVEB antibody; PRR2 antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained from a rabbit immunized with purified, recombinant Human CD112 / Nectin-2 (rh CD112 / Nectin-2; NP_002847.1; Met1-Leu360) and conjugated with PE under optimum conditions, the unreacted PE was removed.
  • Clonality
    Monoclonal
  • Formulation
    Aqueous solution containing 0.5% BSA and 0.09% sodium azide
  • Storage instructions
    This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
    Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
  • Applications
    FCM
  • Validations

    CD112 / Nectin-2 / PVRL2 Antibody (PE), Rabbit MAb, Flow cytometric

    CD112 / Nectin-2 / PVRL2 Antibody (PE), Rabbit MAb, Flow cytometric

    Flow cytometric analysis of anti-Human PVRL2(CD112) on A549 cells.

  • Background
    Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and thus is involved in cell to cell spreading of these viruses. CD112 protein has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 protein can induce NK cell- and CD8+ T cell-mediated cytotoxicity and cytokine secretion. CD112 has been regarded as a critical component in allergic reactions, and accordingly may function as a novel target for anti-allergic therapy.
  • References
    • Bachelet I, et al. (2006) Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process. J Biol Chem. 281(37): 27190-6.
    • Wang L, et al. (2009) Molecular cloning, characterization and three-dimensional modeling of porcine nectin-2/CD112. Vet Immunol Immunopathol. 132(2-4): 257-63.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"