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  • Anti-Carboxypeptidase M/CPM antibody

Anti-Carboxypeptidase M/CPM antibody

Cat.#: 105667

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Product Information

  • Product Name
    Anti-Carboxypeptidase M/CPM antibody
  • Documents
  • Description
    Rabbit polyclonal to Carboxypeptidase M/CPM
  • Tested applications
    ELISA
  • Species reactivity
    Mouse Carboxypeptidase M / CPM
  • Alternative names
    1110060I01Rik antibody; 5730456K23Rik antibody; AA589379 antibody; Carboxypeptidase M antibody; Carboxypeptidase M antibody; Cpm antibody; CPM antibody; E030045M14Rik antibody; MGC118152 antibody; AA589379 antibody; 1110060I01Rik antibody; 5730456K23Rik antibody; E030045M14Rik antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    Produced in rabbits immunized with purified, recombinant Mouse Carboxypeptidase M / CPM (rh CPM; Q80V42-1; Met1-His422). Total IgG was purified by Protein A affinity chromatography.
  • Clonality
    Polyclonal
  • Formulation
    0.2 μm filtered solution in PBS
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
  • Applications

    ELISA: 0.5-1 μg/mL

    This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Mouse Carboxypeptidase M / CPM. The detection limit for Mouse Carboxypeptidase M / CPM is <0.039 ng/well.

  • Validations
  • Background
    Carboxypeptidase M, also known as CPM, is a membrane-bound arginine/lysine carboxypeptidase which is a member of the carboxypeptidases family. These enzymes remove C-terminal amino acids from peptides and proteins and exert roles in the physiological processes of blood coagulation/fibrinolysis, inflammation, food digestion and pro-hormone and neuropeptide processing. Among the carboxypeptidases CPM is of particular importance because of its constitutive expression in an active form at the surface of specialized cells and tissues in the human body. CPM in the brain appears to be membrane-bound via a phosphatidylinositol glycan anchor. CPM is widely distributed in a variety of tissues and cells. The amino acid sequence of CPM indicated that the C-terminal hydrophobic region might be a signal for membrane attachment via a glycosylphosphatidylinositol (GPI) anchor. CPM is involved in peptide metabolism on both the cell surface and in extracellular fluids. CPM functions not only as a protease but also as a binding partner in cell-surface protein-protein interactions.
  • References
    • Deddish PA. et al., 1990, J Biol Chem. 265 (25): 15083-9.
    • Nagae A. et al., 1992, J Neurochem. 59 (6): 2201-12.
    • Skidgel RA. et al., 1996, Immunopharmacology. 32 (1-3): 48-52.
    • Deiteren K. et al., 2009, Clin Chim Acta. 399 (1-2): 24-39.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"