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  • Anti-Carboxypeptidase A1/CPA1 antibody

Anti-Carboxypeptidase A1/CPA1 antibody

Cat.#: 102579

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Product Information

  • Product Name
    Anti-Carboxypeptidase A1/CPA1 antibody
  • Documents
  • Description
    Rabbit polyclonal to Carboxypeptidase A1/CPA1
  • Tested applications
    ELISA
  • Species reactivity
    Mouse CPA1 / Carboxypeptidase-A1
  • Alternative names
    0910001L12Rik antibody; Carboxypeptidase A1 antibody; Carboxypeptidase A1 antibody; Cpa antibody; CPA antibody; Cpa1 antibody; CPA1 antibody; Cpa antibody; 0910001L12Rik antibody; CPA antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    Produced in rabbits immunized with purified, recombinant Mouse CPA1 (rM CPA1; NP_079626.2; Met 1-Tyr 419). Total IgG was purified by Protein A affinity chromatography.
  • Clonality
    Polyclonal
  • Formulation
    0.2 μm filtered solution in PBS with 5% trehalose
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    ELISA: 0.5-1 μg/mL

    This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Mouse CPA1. The detection limit for Mouse CPA1 is 0.0049 ng/well.

  • Validations
  • Background
    Human Carboxypeptidase A1 (CPA1)is secreted as a pancreatic procarboxypeptidase, and cleaves the C-terminal amide or ester bond of peptides that have a free C-terminal carboxyl group, with the preference of  residues with aromatic or branched aliphatic side chains. CPA1 comprises a signal peptide, a pro region and a mature chain, and can be activated after cleavage of the pro peptide. In contrast to procarboxypeptidase B which was always secreted by the pancreas as a monomer, procarboxypeptidase A occurs as a monomer and/or associated to one or two functionally different proteins, such as zymogen E, and is involved in zymogen inhibition. Three different forms of human pancreatic procarboxypeptidase A have been isolated.
  • References
    • Catasus, L. et al., 1992, Biochem. J. 287: 299-303.
    • Moulard, M. et al., 1990, FEBS. Lett. 261: 179-183.
    • Aloy, P. et al., 1998, Biol. Chem. 379: 149-155.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"