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  • Anti-c-Met/HGFR antibody

Anti-c-Met/HGFR antibody

Cat.#: 104625

Special Price 161.3 USD

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Product Information

  • Product Name
    Anti-c-Met/HGFR antibody
  • Documents
  • Description
    Rabbit monoclonal to c-Met/HGFR
  • Tested applications
  • Species reactivity
    Human HGFR / c-MET
  • Alternative names
    HGFR antibody; AUTS9 antibody; RCCP2 antibody; c-Met antibody; HGF antibody; HGFR antibody; Par4 antibody; c-Met antibody; AI838057 antibody; AI838057 antibody; AUTS9 antibody; c-Met antibody; c-MET antibody; HGF antibody; HGFR antibody; HGFR antibody; Met antibody; MET antibody; Par4 antibody; RCCP2 antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained from a rabbit immunized with purified, recombinant Human HGFR / c-MET (rh HGFR / c-MET; NP_000236; Met 1-Thr 932) and conjugated with APC under optimum conditions, the unreacted APC was removed.
  • Clonality
  • Formulation
    Aqueous solution containing 0.5% BSA and 0.09% sodium azide
  • Storage instructions
    This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
    Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
  • Applications
  • Validations

    c-MET / HGFR Antibody (APC), Rabbit MAb, Flow cytometric analysis

    c-MET / HGFR Antibody (APC), Rabbit MAb, Flow cytometric analysis

    Profile of anti-human C-Met (HGF R) reactivity on HepG2 cells analyzed by flow cytometry. The Clone R271 and R243 (Cat. No. 10692-R243-A) monoclonal antibodies are not cross-blocking.

  • Background
    Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that has been shown to be overexpressed and/or mutated in a variety of malignancies. HGFR protein is produced as a single-chain precursor, and HGF is the only known ligand. Normal HGF/HGFR signaling is essential for embryonic development, tissue repair or wound healing, whereas aberrantly active HGFR has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes. HGFR protein is a multifaceted regulator of growth, motility, and invasion, and is normally expressed by cells of epithelial origin. Preclinical studies suggest that targeting aberrant HGFR signaling could be an attractive therapy in cancer.
  • References
    • McGill GG, et al. (2006) c-Met expression is regulated by Mitf in the melanocyte lineage. J Biol Chem. 281(15): 10365-73.
    • Garcia S, et al. (2007) c-Met overexpression in inflammatory breast carcinomas: automated quantification on tissue microarrays. British journal of cancer. 96(2): 329-35.
    • Socoteanu MP, et al. (2008) c-Met targeted therapy of cholangiocarcinoma. World J Gastroenterol. 14(19): 2990-4.
    • Kong DS, et al. (2009) Prognostic significance of c-Met expression in glioblastomas. Cancer. 115(1): 140-8.