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  • Anti-c-Met/HGFR antibody

Anti-c-Met/HGFR antibody

Cat.#: 101225

Special Price 290.3 USD

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Product Information

  • Product Name
    Anti-c-Met/HGFR antibody
  • Documents
  • Description
    Rabbit monoclonal to c-Met/HGFR
  • Tested applications
  • Species reactivity
    Human c-Met / HGFR
    Has cross-reactivity with Cynomolgus/Rhesus C-Met (90304-C08H) in ELISA assay
    No cross-reactivity with Mouse C-Met (50622-M08H) in ELISA assay
  • Alternative names
    HGFR antibody; AUTS9 antibody; RCCP2 antibody; c-Met antibody; HGF antibody; HGFR antibody; Par4 antibody; c-Met antibody; AI838057 antibody; AI838057 antibody; AUTS9 antibody; c-Met antibody; c-MET antibody; HGF antibody; HGFR antibody; HGFR antibody; Met antibody; MET antibody; Par4 antibody; RCCP2 antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained from a rabbit immunized with purified, recombinant Human c-Met / HGFR (rh c-Met / HGFR; NP_000236; Met1-Thr932) and was produced using recombinant antibody technology.
  • Clonality
  • Formulation
    0.2 μm filtered solution in Histidine and Arginine buffer containing 120mM NaCl, 0.02% Tween 80, pH6.0
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications
    Block - This antibody can block the binding of recombinant human HGF to its recombinant receptor HGFR.
    Neutralization - The neutralization activity of HGFR Neutralizing Antibody is Measured by its ability to neutralize HGF induced proliferation in the U87 human glioma cell line.
  • Validations

    c-Met / HGFR Neutralizing Antibody

    c-Met / HGFR Neutralizing Antibody

    Cell Proliferation was Inhibited by Human HGFR Antibody. Proliferation elicited by autocrine HGF is neutralized by increasing concentrations of Human HGFR Monoclonal Antibody (Catalog 10692-R615).

  • Background
    Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that has been shown to be overexpressed and/or mutated in a variety of malignancies. HGFR protein is produced as a single-chain precursor, and HGF is the only known ligand. Normal HGF/HGFR signaling is essential for embryonic development, tissue repair or wound healing, whereas aberrantly active HGFR has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes. HGFR protein is a multifaceted regulator of growth, motility, and invasion, and is normally expressed by cells of epithelial origin. Preclinical studies suggest that targeting aberrant HGFR signaling could be an attractive therapy in cancer.
  • References
    • McGill GG, et al. (2006) c-Met expression is regulated by Mitf in the melanocyte lineage. J Biol Chem. 281(15): 10365-73.
    • Garcia S, et al. (2007) c-Met overexpression in inflammatory breast carcinomas: automated quantification on tissue microarrays. British journal of cancer. 96(2): 329-35.
    • Socoteanu MP, et al. (2008) c-Met targeted therapy of cholangiocarcinoma. World J Gastroenterol. 14(19): 2990-4.
    • Kong DS, et al. (2009) Prognostic significance of c-Met expression in glioblastomas. Cancer. 115(1): 140-8.