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  • Anti-c-Met/HGFR antibody

Anti-c-Met/HGFR antibody

Cat.#: 100641


Special Price 193.4 USD

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Product Information

  • Product Name
    Anti-c-Met/HGFR antibody
  • Documents
  • Description
    Rabbit monoclonal to c-Met/HGFR
  • Tested applications
  • Species reactivity
    Human c-MET / HGFR
  • Alternative names
    HGFR antibody; AUTS9 antibody; RCCP2 antibody; c-Met antibody; HGF antibody; HGFR antibody; Par4 antibody; c-Met antibody; AI838057 antibody; AI838057 antibody; AUTS9 antibody; c-Met antibody; c-MET antibody; HGF antibody; HGFR antibody; HGFR antibody; Met antibody; MET antibody; Par4 antibody; RCCP2 antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained from a rabbit immunized with purified, recombinant Human c-MET / HGFR (rh c-MET / HGFR; NP_000236; Met1-Thr932).
  • Clonality
  • Formulation
    0.2 μm filtered solution in PBS with 5% trehalose
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    ELISA: 0.5-1 μg/mL

    This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Human c-MET / HGFR. The detection limit for Human c-MET / HGFR is approximately 0.16 ng/well.

    FCM: 0.5-2 μg/Test

  • Validations

    c-Met / HGFR Antibody, Rabbit MAb, Flow cytometric analysis

    c-Met / HGFR Antibody, Rabbit MAb, Flow cytometric analysis

    Flow cytometric analysis of Human C-Met(HGFR) expression on HepG2 cells. Cells were stained with purified anti-Human C-Met(HGFR), then a FITC-conjugated second step antibody. The histogram were derived from gated events with the forward and side light-scatter characteristics of intact cells.

  • Background
    Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that has been shown to be overexpressed and/or mutated in a variety of malignancies. HGFR protein is produced as a single-chain precursor, and HGF is the only known ligand. Normal HGF/HGFR signaling is essential for embryonic development, tissue repair or wound healing, whereas aberrantly active HGFR has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes. HGFR protein is a multifaceted regulator of growth, motility, and invasion, and is normally expressed by cells of epithelial origin. Preclinical studies suggest that targeting aberrant HGFR signaling could be an attractive therapy in cancer.
  • References
    • McGill GG, et al. (2006) c-Met expression is regulated by Mitf in the melanocyte lineage. J Biol Chem. 281(15): 10365-73.
    • Garcia S, et al. (2007) c-Met overexpression in inflammatory breast carcinomas: automated quantification on tissue microarrays. British journal of cancer. 96(2): 329-35.
    • Socoteanu MP, et al. (2008) c-Met targeted therapy of cholangiocarcinoma. World J Gastroenterol. 14(19): 2990-4.
    • Kong DS, et al. (2009) Prognostic significance of c-Met expression in glioblastomas. Cancer. 115(1): 140-8.