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  • Anti-B7-DC/PD-L2/CD273 antibody

Anti-B7-DC/PD-L2/CD273 antibody

Cat.#: 100136

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Product Information

  • Product Name
    Anti-B7-DC/PD-L2/CD273 antibody
  • Documents
  • Description
    Rabbit monoclonal to B7-DC/PD-L2/CD273
  • Tested applications
  • Species reactivity
    Human B7-DC / PD-L2 / CD273 / PDCD1LG2
  • Alternative names
    B7DC antibody; B7-DC antibody; bA574F11.2 antibody; Btdc antibody; Btdc antibody; CD273 antibody; F730015O22Rik antibody; MGC124039 antibody; MGC124040 antibody; MGC142238 antibody; MGC142240 antibody; PDCD1L2 antibody; PDCD1LG2 antibody; Pdcd1lg2 antibody; PDL2 antibody; PD-L2 antibody; PD-L2 antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained from a rabbit immunized with purified, recombinant Human B7-DC / PD-L2 / CD273 / PDCD1LG2 (rh B7-DC / PD-L2 / CD273 / PDCD1LG2; NP_079515.2; Met1-Pro219) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
  • Clonality
  • Formulation
    Aqueous solution containing 0.5% BSA and 0.09% sodium azide
  • Storage instructions
    This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
    Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
  • Applications
  • Validations

    B7-DC / PD-L2 / CD273 / PDCD1LG2 Antibody, Rabbit MAb, Flow Cytometry

    B7-DC / PD-L2 / CD273 / PDCD1LG2 Antibody, Rabbit MAb, Flow Cytometry

    Flow cytometric analysis of Human PDL2(CD273) expression on monocyte-derived dendritic cells. Cells were stained with FITC-conjugated anti-Human PDL2(CD273). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.

  • Background
    Programmed death ligand 2 (PD-L2), also referred to as B7-DC and CD273, is a member of the B7 family of proteins including B7-1, B7-2, B7-H2, B7-H1 (PD-L1), and B7-H3. PD-L2 is a type I membrane protein and structurally consists of an extracellular region containing one V-like and one C-like Ig domain, a transmembrane region, and a short cytoplasmic domain. PD-L2 is expressed on antigen presenting cells, placental endothelium and medullary thymic epithelial cells, and can be induced by LPS in B cells, INF-γ in monocytes, or LPS plus IFN-γ in dendritic cells. The CD28 and B7 protein families are critical regulators of immune responses. PD-L2 and PD-L1 are two ligands for PD-1, member of the CD28/CTLA4 family expressed on activated lymphoid cells, and thus provide signals for regulating T cell activation and immune tolerance. The interaction of B7-DC/PD-1 exhibited a 2-6-fold higher affinity compared with the interaction of B7-H1/PD-1.
  • References
    • Latchman Y, et al. (2001) PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol. 2: 261-8.
    • Carreno BM, et al. (2005) Therapeutic opportunities in the B7/CD28 family of ligands and receptors. Curr Opin Pharmacol. 5(4): 424-30.
    • Radhakrishnan S, et al. (2007) B7-DC/PD-L2 cross-linking induces NF-kappaB-dependent protection of dendritic cells from cell death. J Immunol. 178(3): 1426-32.