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  • Anti-AK4 / Adenylate Kinase 4 / AK3L1 antibody

Anti-AK4 / Adenylate Kinase 4 / AK3L1 antibody

Cat.#: 104735

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Product Information

  • Product Name
    Anti-AK4 / Adenylate Kinase 4 / AK3L1 antibody
  • Documents
  • Description
    Rabbit polyclonal to AK4 / Adenylate Kinase 4 / AK3L1
  • Tested applications
  • Species reactivity
    Human AK4 / Adenylate Kinase 4 / AK3L1
  • Alternative names
    AK3L1 antibody; AK-3 antibody; Ak3l1 antibody; AK3 antibody; AK4 antibody; AK3L2 antibody; Ak3 antibody; AK4 antibody; Ak-4 antibody; D4Ertd274e antibody; AK3 antibody; Ak3 antibody; Ak-3 antibody; Ak3l1 antibody; AK3L1 antibody; AK3L2 antibody; Ak4 antibody; AK4 antibody; Ak-4 antibody; D4Ertd274e antibody; RP23-301M3.3 antibody; RP4-686B20.1 antibody; MGC166959 antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    Produced in rabbits immunized with purified, recombinant Human AK4 / Adenylate Kinase 4 / AK3L1 (rh AK4; P27144-1; Ala2-Tyr223). Total IgG was purified by Protein A affinity chromatography.
  • Clonality
  • Formulation
    0.2 μm filtered solution in PBS
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
  • Applications

    ELISA: 0.5-1 μg/mL

    This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Human AK4 / Adenylate Kinase 4 / AK3L1. The detection limit for Human AK4 / Adenylate Kinase 4 / AK3L1 is <0.039 ng/well.

  • Validations
  • Background
    Adenylate kinase isoenzyme 4, mitochondrial, also known as ATP-AMP transphosphorylase, Adenylate kinase 3-like, AK4 and AK3L1, is a member the adenylate kinase family. AK4 / AK3L1 is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. AK4 / AK3L1 catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. It may also be active with GTP. Adenylate kinase 4 ( AK4 / AK3L1 ) is a unique member with no enzymatic activity in the adenylate kinase (AK) family although it shares high sequence homology with other AKs. It remains unclear what physiological function AK4 might play or why it is enzymatically inactive. AK4 / AK3L1 retains the capability of binding nucleotides. It has a glutamine residue instead of a key arginine residue in the active site well conserved in other AKs. The enzymatically inactive AK4 is a stress responsive protein critical to cell survival and proliferation. AK4 / AK3L1 is likely that the interaction with the mitochondrial inner membrane protein ANT is important for AK4 to exert the protective benefits to cells under stress. AK4 / AK3L1 also acts on the specific mechanism of energy metabolism rather than control of the homeostasis of the ADP pool ubiquitously.
  • References