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  • Amyloid β/A4 Protein Precursor770 (586-595) (human, mouse, rat) peptide

Amyloid β/A4 Protein Precursor770 (586-595) (human, mouse, rat) peptide

Not For Human Use, Lab Use Only.

Cat.#: 313231

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* Buy 1 get 1 free (?) What is TFA?

Special Price 126.50 USD

Availability: 1-2 weeks
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Product Information

  • Product Name
    Amyloid β/A4 Protein Precursor770 (586-595) (human, mouse, rat) peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    ISYGNDALMP
  • Sequence
    Ile-Ser-Tyr-Gly-Asn-Asp-Ala-Leu-Met-Pro
  • Length (aa)
    10
  • Peptide Purity (HPLC)
    96.6%
  • Molecular Formula
    C47H73N11O16S
  • Molecular Weight
    1080.23
  • Source
    Synthetic
  • Form
    Powder
  • Description
    Amyloid β/A4 Protein Precursor770 (586-595) (human, mouse, rat) also known as APP-derived inhibitory peptide (APP-IP), efficiently inhibited the activity of gelatinase A (matrix metalloproteinase-2 (MMP-2)) (IC50 = 30 nM), whereas its inhibitory activity towards membrane type 1-matrix metalloproteinase was much weaker (IC50 = 2 µM). The decapeptide ISYGNDALMP had poor inhibitory activity towards gelatinase B, matrilysin or stromelysin (IC50 > 10 µM). APP-IP is likely an active site-directed inhibitor of gelatinase A. Clarification of its mode of action might provide a lead for the design of novel anti-cancer drugs that block specific processes of tumor invasion and angiogenesis.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight

Peptide Property

  • Analysed Sequence:H-ISYGNDALMP-OH
  • Chemical Formula:C47H73N11O16S
  • Sequence length:10
  • Extinction coefficient:1280 M-1cm-1
  • GRAVY:0.09
  • Mw average:1080.21
  • Theoretical pI:3.12
  • Data Source:Peptide Property Calculator

GRAVY = grand average of hydropathy

X: Hydrophobic uncharged residues, like F I L M V W A and P

X: Basic residues, like R K H

X: Acidic residues, like D E

X: Polar uncharged residues, like G S T C N Q and Y

• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"