Hydrophobic patches, defined as clusters of neighboring apolar atoms deemed accessible on a given protein surface, can often be linked to a biological role. Hydrophobic patchy domains drastically reduce the inter-protein interactions and are efficient in disaggregating proteins.
This online tool could used to detect hydrophobic patches on protein surfaces
1. Sequence (Paste the raw sequence, not fasta format):
Please upload the model file of the protein (only .pdb format is accepted):
References
- 1. Lijnzaad, P., Berendsen, H.J.C. and Argos, P. (1996) "A method for detecting hydrophobic patches on the protein surfaces." Proteins: Structure, Function, Genetics 26:192-203.