ZBTB7B antibody

ZBTB7B antibody

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• Material Safety Data Sheets (MSDS)

ZBTB7B Rabbit Polyclonal antibody. Positive IP detected in mouse skin tissue. Positive WB detected in human skin tissue. Positive IF detected in Hela cells, MCF-7 cells. Observed molecular weight by Western-blot: 58kd

ELISA, WB, IF, IP

Human,Mouse,Rat; other species not tested.

c Krox antibody; DKFZp686G01254 antibody; hcKrox antibody; THPOK antibody; ZBTB15 antibody; ZBTB7B antibody; Zfp 67 antibody; ZFP67 antibody; Zinc finger protein 67 homolog antibody; Zinc finger protein Th POK antibody; ZNF857B antibody

Rabbit IgG

This antibody was obtained by immunization of ZBTB7B recombinant protein (Accession Number: XM_047421863). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

ZBTB7B belongs to a large family of transcription factors, generally acting as repressors, characterized by a carboxy-terminal DNA binding domain made of multiple zinc fingers (four in Thpok) and an amino-terminal BTB-POZ domain that mediates homo- (and possibly hetero-) dimerization [PMID: 17084908]. Zbtb7b is up-regulated by MHC-II-restricted thymocytes during their CD4 differentiation and is a major determinant of CD4 lineage choice. Two properties of ZBTB7B deserve attention. First, although Thpok is expressed in a wide variety of cells, its expression in the thymus is highly lineage-specific: CD4 SP thymocytes (and all CD4 T cells) express Thpok, whereas DP and CD8 SP thymocytes do notSecond, both loss- and gain-of-function experiments indicate that Thpok affects lineage choice but not positive selection [PMID: 15729333, 10550051].