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Product Name
XPO6 antibody
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Description
XPO6 Rabbit Polyclonal antibody. Positive IP detected in HeLa cells. Positive IHC detected in human ovary tissue, human heart tissue, human kidney tissue, human lung tissue, human placenta tissue, human skin tissue, human testis tissue. Observed molecular weight by Western-blot: 135 kDa
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Tested applications
ELISA, IHC, IP
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
EXP6 antibody; exportin 6 antibody; FLJ22519 antibody; KIAA0370 antibody; Ran binding protein 20 antibody; RANBP20 antibody; XPO6 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of XPO6 recombinant protein (Accession Number: BC014071). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
IP: 1:200-1:1000
IHC: 1:10-1:100
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Validations
Immunohistochemical of paraffin-embedded human ovary using Catalog No:116994(XPO6 antibody) at dilution of 1:25 (under 10x lens)
Immunohistochemical of paraffin-embedded human ovary using Catalog No:116994(XPO6 antibody) at dilution of 1:25 (under 40x lens)
IP Result of anti-XPO6 (IP:Catalog No:116994, 4ug; Detection:Catalog No:116994 1:300) with HeLa cells lysate 2000ug.
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Background
Human XPO6 gene encodes a Ran-binding protein 20, exportin-6, belonging to the exportin family. Exportin-6 shuttles between the nucleus and the cytoplasm and mediates the nuclear export of actin and profilin-actin complexes in somatic cells. Interaction of exportin-6 and actin is achieved in a RanGTP-dependent manner, actin is a major cytoskeletal element which is normally kept cytoplasmic by exportin-6 driven nuclear export.
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References
- Ambs S, Prueitt RL, Yi M. Genomic profiling of microRNA and messenger RNA reveals deregulated microRNA expression in prostate cancer. Cancer research. 68(15):6162-70. 2008.
- Dopie J, Skarp KP, Rajakylä EK, Tanhuanpää K, Vartiainen MK. Active maintenance of nuclear actin by importin 9 supports transcription. Proceedings of the National Academy of Sciences of the United States of America. 109(9):E544-52. 2012.
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