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Product Name
XIAP antibody
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Description
XIAP Rabbit Polyclonal antibody. Positive WB detected in Jurkat cells, C6 cells, HEK-293 cells, HeLa cells, Tunicamycin treated HepG2 cells. Observed molecular weight by Western-blot: 45-50 kDa
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Tested applications
ELISA, WB
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Species reactivity
Human, Rat; other species not tested.
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Alternative names
API3 antibody; BIRC4 antibody; hIAP 3 antibody; hIAP3 antibody; hILP antibody; IAP 3 antibody; IAP like protein antibody; IAP3 antibody; ILP antibody; ILP1 antibody; MIHA antibody; X linked IAP antibody; XIAP antibody; XLP2 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of XIAP recombinant protein (Accession Number: NM_001204401). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
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Validations
Jurkat cells were subjected to SDS PAGE followed by western blot with Catalog No:116985(XIAP antibody) at dilution of 1:1000
Tunicamycin treated HepG2 cells were subjected to SDS PAGE followed by western blot with Catalog No:116985(XIAP Antibody) at dilution of 1:600
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Background
XIAP, also named as API3, BIRC4 and IAP3, belongs to the IAP family. It has E3 ubiquitin-protein ligase activity. It mediates the proteasomal degradation of target proteins, such as caspase-3, SMAC or AIFM1. XIAP is an inhibitor of caspase-3, -7 and -9. It mediates activation of MAP3K7/TAK1, leading to the activation of NF-kappa-B. XIAP is an apoptotic suppressor. It is ubiquitinated and degraded by the proteasome in apoptotic cells. The MW of XIAP is 45-56kd.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"