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WWOX antibody

Cat.#: 116977

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Product Information

  • Product Name
    WWOX antibody
  • Documents
  • Description
    WWOX Rabbit Polyclonal antibody. Positive WB detected in mouse skeletal muscle tissue, human testis tissue. Positive IP detected in mouse skeletal muscle tissue. Observed molecular weight by Western-blot: 46 kDa
  • Tested applications
    ELISA, WB, IP
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    D16S432E antibody; FOR antibody; FRA16D antibody; HHCMA56 antibody; PRO0128 antibody; SDR41C1 antibody; WOX1 antibody; WWOX antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of WWOX recombinant protein (Accession Number: NM_130788). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IP: 1:200-1:2000

  • Validations

    mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with Catalog No:116977(WWOX antibody) at dilution of 1:300

    mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with Catalog No:116977(WWOX antibody) at dilution of 1:300

    IP Result of anti-WWOX (IP:Catalog No:116977, 4ug; Detection:Catalog No:116977 1:500) with mouse skeletal muscle tissue lysate 4000ug.

    IP Result of anti-WWOX (IP:Catalog No:116977, 4ug; Detection:Catalog No:116977 1:500) with mouse skeletal muscle tissue lysate 4000ug.

  • Background
    WWOX(WW domain-containing oxidoreductase) is also named as FOR, WOX1 and belongs to the short-chain dehydrogenases/reductases (SDR) family. The gene encodes a 46 kDa protein that contains two WW domains and a short-chain dehydrogenase/reductase domain and the protein is lost or reduced in the majority of many cancer types including breast, prostate, esophageal, lung, stomach, and pancreatic carcinomas and in a large fraction of other cancer types(PMID:17360458). WWOX behaves as a potential tumor-suppressor gene(PMID:15064722). It has 7 isoforms produced by alternative splicing.
  • References
    • Qu J, Lu W, Li B, Lu C, Wan X. WWOX induces apoptosis and inhibits proliferation in cervical cancer and cell lines. International journal of molecular medicine. 31(5):1139-47. 2013.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"