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WDR18 antibody

Cat.#: 116857

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Product Information

  • Product Name
    WDR18 antibody
  • Documents
  • Description
    WDR18 Rabbit Polyclonal antibody. Positive WB detected in Jurkat cells. Positive IHC detected in human ovary tumor tissue, human lung cancer tissue. Observed molecular weight by Western-blot: 47 kDa
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human; other species not tested.
  • Alternative names
    R32184_1 antibody; WD repeat domain 18 antibody; WDR18 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of WDR18 recombinant protein (Accession Number: NM_024100). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

    IHC: 1:20-1:200

  • Validations

    Jurkat cells were subjected to SDS PAGE followed by western blot with Catalog No:116857(WDR18 antibody) at dilution of 1:500

    Jurkat cells were subjected to SDS PAGE followed by western blot with Catalog No:116857(WDR18 antibody) at dilution of 1:500

    Immunohistochemical of paraffin-embedded human ovary tumor using Catalog No:116857(WDR18 antibody) at dilution of 1:100 (under 40x lens)

    Immunohistochemical of paraffin-embedded human ovary tumor using Catalog No:116857(WDR18 antibody) at dilution of 1:100 (under 40x lens)

    Immunohistochemical of paraffin-embedded human ovary tumor using Catalog No:116857(WDR18 antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human ovary tumor using Catalog No:116857(WDR18 antibody) at dilution of 1:100 (under 10x lens)

  • Background
    WDR18 is a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. WDR18 may play a role during development. The complex PELP1–TEX10–WDR18 is required for the maturation and nucleolar release of the large ribosomal subunit. This complex is a regulator of ribosome biogenesis and suggests that its SUMO-controlled distribution coordinates the rate of ribosome formation (PMID:21326211).
  • References
    • Finkbeiner E, Haindl M, Muller S. The SUMO system controls nucleolar partitioning of a novel mammalian ribosome biogenesis complex. The EMBO journal. 30(6):1067-78. 2011.
    • Fanis P, Gillemans N, Aghajanirefah A. Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation. Molecular & cellular proteomics : MCP. 11(11):1263-73. 2012.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"