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Product Name
WBP1 antibody
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Description
WBP1 Rabbit Polyclonal antibody. Positive WB detected in MCF7 cells. Positive IHC detected in human pancreas cancer tissue. Observed molecular weight by Western-blot: 29-32 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human; other species not tested.
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Alternative names
WBP 1 antibody; WBP1 antibody; WW domain binding protein 1 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of WBP1 recombinant protein (Accession Number: NM_012477). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:1000
IHC: 1:20-1:200
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Validations
MCF7 cells were subjected to SDS PAGE followed by western blot with Catalog No:116845(WBP1 antibody) at dilution of 1:400
Immunohistochemical of paraffin-embedded human pancreas cancer using Catalog No:116845(WBP1 antibody) at dilution of 1:50 (under 10x lens)
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Background
WBP1 was originally identified in vitro as a protein that bound to the WW domain of Yes kinase-associated protein. The silencing of WBP1 with small hairpin RNAs caused partial, but significant suppression of ATF6-induced apoptosis. It is a type I transmembrane protein.
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References
- Morishima N, Nakanishi K, Nakano A. Activating transcription factor-6 (ATF6) mediates apoptosis with reduction of myeloid cell leukemia sequence 1 (Mcl-1) protein via induction of WW domain binding protein 1. The Journal of biological chemistry. 286(40):35227-35. 2011.
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