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Product Name
WAPL; WAPAL antibody
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Description
WAPL; WAPAL Rabbit Polyclonal antibody. Positive WB detected in HL-60 cells, Jurkat cells. Observed molecular weight by Western-blot: 140kd
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Tested applications
ELISA, WB
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
FOE antibody; Friend of EBNA2 protein antibody; KIAA0261 antibody; WAPAL antibody; WAPL antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of WAPL; WAPAL recombinant protein (Accession Number: BC017393). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
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Validations
HL-60 cells were subjected to SDS PAGE followed by western blot with Catalog No:116840(WAPL; WAPAL antibody) at dilution of 1:300
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Background
The wings apart-like (WAPL, or WAPAL) protein was originally identified as a gene product that potentially regulates heterochromatin organization in Drosophila melanogaster. Human WAPL is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase. Overexpression of WAPL disturbs mitosis and cytokinesis, and contributes to tumor progression by induction of chromosomal instability.
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References
- Sun Y, Tawara I, Zhao M. Allogeneic T cell responses are regulated by a specific miRNA-mRNA network. The Journal of clinical investigation. 123(11):4739-54. 2013.
- Minamino M, Ishibashi M, Nakato R. Esco1 Acetylates Cohesin via a Mechanism Different from That of Esco2. Current biology : CB. 25(13):1694-706. 2015.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"