VDR antibody

Cat.#: 116734

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Product Information

  • Product Name
    VDR antibody
  • Documents
  • Description
    VDR Rabbit Polyclonal antibody. Positive WB detected in PC-3 cells. Observed molecular weight by Western-blot: 55 kDa
  • Tested applications
    ELISA, WB
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    NR1I1 antibody; VDR antibody; Vitamin D3 receptor antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of VDR recombinant protein (Accession Number: XM_047429500). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

  • Validations

    PC-3 cells were subjected to SDS PAGE followed by western blot with Catalog No:116734(VDR Antibody) at dilution of 1:1000

    PC-3 cells were subjected to SDS PAGE followed by western blot with Catalog No:116734(VDR Antibody) at dilution of 1:1000

  • Background
    The vitamin D receptor (VDR), also known as the calcitriol receptor, and also known as NR1I1 (nuclear receptor subfamily 1, group I, member 1), is a member of the nuclear receptor family of transcription factors. Upon activation by vitamin D, the VDR forms a heterodimer with the retinoid-X receptor and binds to hormone response elements on DNA resulting in expression or trans-repression of specific gene products.It is an intracellular hormone receptor that specifically binds 1,25(OH)2D3 and mediates its effects. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Defects in VDR are the cause of rickets vitamin D-dependent type 2A (VDDR2A). A disorder of vitamin D metabolism results in severe rickets, hypocalcemia and secondary hyperparathyroidism. Most patients have total alopecia in addition to rickets. This antibody is a rabbit polyclonal antibody to human VDR.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"