USP18 antibody

USP18 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

USP18 Rabbit Polyclonal antibody. Positive WB detected in MCF-7. Observed molecular weight by Western-blot: 43 kDa, 70 kDa

ELISA, WB

Human; other species not tested.

43 kDa ISG15 specific protease antibody; hUBP43 antibody; ISG43 antibody; Ubl thiolesterase 18 antibody; UBP43 antibody; USP18 antibody

Rabbit IgG

This antibody was obtained by immunization of USP18 recombinant protein (Accession Number: NM_017414). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

USP18(UBP43) is a 43 kDa protein that is known as an ISG15-deconjugating enzyme and an inhibitor of type I IFN signaling independent of its enzyme activity. USP18 can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds. It can be detected two bands(apparent MW of 38 and 35 kDa), the faster migrating one results from proteolytic processing in human primary hepatocytes(PMID:21779393). Sometimes the 70 kDa band is showed on the SDS-PAGE that it is considered as the ISG15-specific protease UBP43/USP18(PMID: 14673145).