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Product Name
UNC45A antibody
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Description
UNC45A Rabbit Polyclonal antibody. Positive IP detected in K-562 cells. Positive WB detected in mouse ovary tissue, mouse lung tissue. Positive IHC detected in human stomach tissue, human tonsil tissue. Observed molecular weight by Western-blot: 100 kDa
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Tested applications
ELISA, IHC, IP, WB
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
FLJ10043 antibody; GC UNC45 antibody; GCUNC 45 antibody; GCUNC45 antibody; IRO039700 antibody; Protein unc 45 homolog A antibody; SMAP 1 antibody; SMAP1 antibody; unc 45 homolog A (C. elegans) antibody; Unc 45A antibody; UNC45A antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_018671). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:1000
IP: 1:200-1:1000
IHC: 1:20-1:200
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Validations
mouse ovary tissue were subjected to SDS PAGE followed by western blot with Catalog No:116612(UNC45A antibody) at dilution of 1:300
Immunohistochemical of paraffin-embedded human stomach using Catalog No:116612(UNC45A antibody) at dilution of 1:100 (under 10x lens)
Immunohistochemical of paraffin-embedded human stomach using Catalog No:116612(UNC45A antibody) at dilution of 1:100 (under 40x lens)
IP Result of anti-UNC45A (IP:Catalog No:116612, 4ug; Detection:Catalog No:116612 1:300) with K-562 cells lysate 3600ug.
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Background
UNC45A, also named as SMAP1, acts as co-chaperone for HSP90. UNC45A prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. It is a positive factor in promoting PGR function in the cell. It is necessary for proper folding of myosin and necessary for normal cell proliferation, normal myotube formation and myosin accumulation during muscle cell development. UNC45A plays a role in erythropoiesis in stroma cells in the spleen. The antibody recognizes the C-term of UNC45A.
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