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Product Name
UNC13D/Munc13-4 antibody
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Description
UNC13D/Munc13-4 Rabbit Polyclonal antibody. Positive WB detected in Jurkat cells, human placenta tissue. Positive IP detected in Jurkat cells. Positive IHC detected in human spleen tissue, human kidney tissue, human lung tissue, human testis tissue. Observed molecular weight by Western-blot: 120 kDa
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Tested applications
ELISA, WB, IHC, IP
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
FHL3 antibody; HLH3 antibody; HPLH3 antibody; Munc13 4 antibody; Munc13-4 antibody; Protein unc 13 homolog D antibody; unc 13 homolog D (C. elegans) antibody; UNC13D antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of UNC13D/Munc13-4 recombinant protein (Accession Number: NM_199242). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IP: 1:200-1:1000
IHC: 1:20-1:200
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Validations
Jurkat cells were subjected to SDS PAGE followed by western blot with Catalog No:116573(UNC13D antibody) at dilution of 1:300
Immunohistochemical of paraffin-embedded human spleen using Catalog No:116573(UNC13D antibody) at dilution of 1:100 (under 10x lens)
Immunohistochemical of paraffin-embedded human spleen using Catalog No:116573(UNC13D antibody) at dilution of 1:100 (under 40x lens)
IP Result of anti-UNC13D (IP:Catalog No:116573, 5ug; Detection:Catalog No:116573 1:300) with Jurkat cells lysate 2400ug.
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Background
UNC13D represents unc-13 homolog D (C. elegans)
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References
- Meeths M, Chiang SC, Wood SM. Familial hemophagocytic lymphohistiocytosis type 3 (FHL3) caused by deep intronic mutation and inversion in UNC13D. Blood. 118(22):5783-93. 2011.
- Cichocki F, Schlums H, Li H. Transcriptional regulation of Munc13-4 expression in cytotoxic lymphocytes is disrupted by an intronic mutation associated with a primary immunodeficiency. The Journal of experimental medicine. 211(6):1079-91. 2014.
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